Noncancer disease incidence in the atomic bomb survivors: 1958-1986.
Noncancer disease incidence in the atomic bomb survivors: 1958-1986.
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原子弹幸存者中的非癌症疾病发病率：1958-1986。
DOI：
10.2307/3578884
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发表时间：
1993
影响因子：
3.4
通讯作者：
Yutaka Hosoda
中科院分区：
文献类型：
--
作者：
F. Lennie Wong;Michiko Yamada;Hideo Sasaki;Kazunori Kodama;Suminori Akiba;Katsutaro Shimaoka;Yutaka Hosoda
利用1958-1986年成人健康研究队列的纵向资料，我们首次研究了原子弹爆炸幸存者电离辐射暴露与19种非恶性疾病发病率之间的关系。受影响的个人是通过国际疾病分类的三位数代码确定的，这些代码是在根据两年一次的AHS检查期间进行的一般实验室测试、体格检查和病史采集作出诊断后在AHS数据库中编码的。使用最初报告疾病时的AHS检查数据与先前参加的无病检查日期之间的中点估计疾病发作时间。使用被判定为最合适的剂量测定系统86器官剂量。假设采用分层背景发生率的线性相对风险模型进行剂量效应检验。在整个研究期间，检测到子宫肌瘤（P < 0.001），慢性肝病和肝硬化（P = 0.006）和甲状腺疾病（P < 0.0001）的显著额外风险，广义定义为存在一种或多种某些非癌性甲状腺疾病。心肌梗死的发病率在以后几年（1968-1986年）在年轻的严重暴露的AHS受试者中显示出增加（P = 0.03），证实了最近的寿命研究（LSS）非癌症死亡率报告冠心病的结果。子宫肌瘤的发现可作为额外证据，表明良性肿瘤生长可能是辐射照射的结果。我们的研究结果表明，放射参与肝脏疾病的发展与LSS队列中放射剂量导致肝硬化死亡率增加的报告一致。非恶性甲状腺疾病（P = 0.02），暴露的年龄的影响被检测到，与那些暴露谁是20岁以下的风险增加，但不是年龄较大的幸存者。因此，AHS的数据表明，年轻人的甲状腺不仅对恶性肿瘤的发展更敏感，而且对非恶性疾病的发展也更敏感。这些发现独立于甲状腺癌观察到的剂量效应。这项研究还表明，在1958-1986年期间，AHS受试者中透镜混浊的新发病例并不随辐射剂量的增加而增加（P = 0.39）。
Using the longitudinal data of the Adult Health Study (AHS) cohort collected during 1958-1986, we examined for the first time the relationship between exposure to ionizing radiation and the incidence of 19 nonmalignant disorders in the A-bomb survivors. Affected individuals were ascertained through the three-digit codes of the International Classification of Diseases which are encoded in the AHS database subsequent to diagnoses made on the basis of general laboratory tests, physical examinations, and history-taking conducted during biennial AHS examinations. The disease onset time was estimated using the mid-point between the AHS examination data when the disease was initially reported and the previously attended disease-free examination date. Dosimetry System 86 organ doses judged to be most appropriate were used. Tests of dose effects were performed assuming a linear relative risk model with stratified background incidence. For the entire study period, significant excess risk was detected for uterine myoma (P < 0.001), chronic liver disease and cirrhosis (P = 0.006), and thyroid disease (P < 0.0001), defined broadly as the presence of one or more of certain noncancerous thyroid conditions. The incidence of myocardial infarction was shown to be increased (P = 0.03) in later years (1968-1986) among the younger heavily exposed AHS subjects, confirming the results of the recent Life Span Study (LSS) noncancer mortality report on coronary heart disease. The findings for uterine myoma may serve as additional evidence indicating benign tumor growth as a possible consequence of radiation exposure. Our results indicating the involvement of radiation in the development of liver diseases are consistent with the report of increased mortality from liver cirrhosis with radiation dose in the LSS cohort. An effect of age at exposure was detected for nonmalignant thyroid disease (P = 0.02), with an increased risk for those exposed who were under 20 years of age, but not for older survivors. Thus the AHS data suggest that thyroid glands in the young are more radiosensitive not only to the development of malignancies, but also to the development of nonmalignant disorders as well. The findings hold independently of the dose effects observed for thyroid cancer. This study also shows that for the period 1958-1986 new occurrences of lens opacity are not increased with radiation dose (P = 0.39) in the AHS subjects.
影响因子：
158.5
作者：
HANCOCK, SL;COX, RS;MCDOUGALL, IR
通讯作者：
MCDOUGALL, IR