Calorie restriction prevents the development of insulin resistance and impaired lipid metabolism in gestational diabetes offspring
Calorie restriction prevents the development of insulin resistance and impaired lipid metabolism in gestational diabetes offspring
复制标题
热量限制可防止妊娠糖尿病后代出现胰岛素抵抗和脂质代谢受损
DOI：
10.1038/pr.2016.273
复制
发表时间：
2017-04-01
影响因子：
3.6
通讯作者：
Hou, Li-Juan
中科院分区：
文献类型：
--
作者：
Li, Tao;Chen, Keyang;Hou, Li-Juan
背景：妊娠期糖尿病（GDM）对后代的影响是持久的，与胰岛素抵抗、肥胖和II型糖尿病的风险增加有关。热量限制（CR）是预防肥胖和糖尿病的最常见和最有效的营养干预措施之一。方法：采用链脲佐菌素（streptozotocin，STZ）诱导C57 BL/6 J小鼠发生GDM，观察GDM子代在自由采食和限制热量摄入条件下的代谢特征及相关蛋白表达。CR通过降低血浆中甘油三酯和胆固醇水平来调节脂质代谢。结论：GDM是GDM后代发生胰岛素抵抗的高危因素，CR可改善GDM后代发生胰岛素抵抗的不良后果。此外，GDM CR后代肝脏中PTEN活化的特异性降低和Akt磷酸化的增加改善了胰岛素敏感性和脂质代谢。
Background:Gestational diabetes mellitus (GDM) has long-lasting influence on offspring, which is associated with increased risks of insulin resistance, obesity, and type II diabetes mellitus. Calorie restriction (CR) is one of the most common and available nutritional interventions to prevent obesity and diabetes. We are trying to explore the effect of CR on GDM offspring.Methods:The streptozotocin was used to stimulate C57BL/6J mice to develop GDM, a number of metabolic characteristics and related protein expressions were determined in GDM offspring that were fed ad-libitum or treated with calorie restriction.Results:CR reduced body weight and glucose levels in GDM offspring. CR modulated the lipid metabolism by decreasing triglyceride and cholesterol levels in plasma. We also found that the effect of CR on insulin sensitivity may involve in signaling pathway through the regulations of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and protein kinase B (Akt).Conclusion:GDM is a high risk factor for GDM offspring to develop insulin resistance, while CR could ameliorate this adverse outcome. Moreover, the specific decrease in PTEN activation and increase in Akt phosphorylation in livers of GDM offspring with CR improved insulin sensitivity and lipid metabolism.