PENICILLIN-G SODIUM AND CEFTRIAXONE IN THE TREATMENT OF NEUROBORRELIOSIS IN CHILDREN - A PROSPECTIVE-STUDY
PENICILLIN-G SODIUM AND CEFTRIAXONE IN THE TREATMENT OF NEUROBORRELIOSIS IN CHILDREN - A PROSPECTIVE-STUDY
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DOI：
10.1007/bf01644967
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发表时间：
1991-07-01
期刊：
影响因子：
7.5
通讯作者：
SPORK, KD
中科院分区：
文献类型：
--
作者：
MULLEGGER, RR;MILLNER, MM;SPORK, KD
目的：探讨青霉素G钠（PG）与头孢曲松钠（C）治疗小儿急性神经型包柔螺旋体病的上级。在18个月的时间内，77名儿童出现中枢神经系统（CNS）莱姆病的症状。在这些儿童中的23例中，伯氏疏螺旋体特异性脑脊液（CSF）参数证实了神经疏螺旋体病的诊断。这些儿童随机接受静脉（i. v.）PG 400 000 - 500 000 I.U./ I组：静脉注射头孢曲松75-93 mg/kg/d，共14 d;在入院时、治疗后即刻、治疗后3个月、6个月和部分治疗后12个月进行临床检查和一组诊断性实验室参数。在抗生素治疗期间，两组所有儿童的一般状况均显著改善，在观察期内未发生复发。考虑到B的明显和可比的下降。两组儿童的伯氏血清滴度和临床结果（疾病持续时间和至少6个月的随访）表明两种抗生素药物之间没有差异。
A controlled clinical study was set up to examine whether penicillin G sodium (PG) or ceftriaxone (C) is superior in the treatment of acute neuroborreliosis in childhood. Within a time period of 18 months 77 children with symptoms indicative of Lyme borreliosis of the central nervous system (CNS) were seen. In 23 of these children Borrelia burgdorferi specific cerebrospinal fluid (CSF) parameters confirmed the diagnosis of a neuroborreliosis. These children were treated at random with intravenous (i.v.) PG 400,000 - 500,000 I.U./kg/day for 14 days (group I) or with i.v. ceftriaxone 75-93 mg/kg/day for 14 days (group II), respectively. Clinical examination and a set of diagnostic laboratory parameters were done at admission, right after therapy, three, six and partly 12 months after therapy. The general condition of all children in both groups improved dramatically during antibiotic therapy, and no relapse occurred within the observation period. Considering the clear and comparable decrease of B. burgdorferi serum titres and the clinical outcome (duration of disease and follow-up for at least six months) in children of both groups no difference between both antibiotic drugs can be demonstrated.