Cognitive functioning in orthostatic hypotension due to pure autonomic failure
Cognitive functioning in orthostatic hypotension due to pure autonomic failure
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DOI：
10.1007/s10286-006-0318-7
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发表时间：
2006-04-01
影响因子：
5.8
通讯作者：
Cipolotti, L
中科院分区：
文献类型：
--
作者：
Heims, HC;Critchley, HD;Cipolotti, L
心理生理科学提出认知过程和自主反应之间存在密切的相互作用，但自主神经失败对认知功能的影响尚未有记录。这项试点研究首次调查了 14 名纯自主神经衰竭 (PAF) 患者的认知状况。每个患者都接受了一系列全面的神经心理学测试和神经影像学检查。许多患者（n = 6）出现认知障碍。两种最常见的损伤类型是：速度和注意力缺陷以及执行功能缺陷。自由回忆记忆、智力功能、名义和计算功能的损伤也被记录在案，尽管频率要低得多。这些认知变化并不总是与白质异常相关。我们推测与 PAF 相关的认知障碍代表了全身性低血压和脑灌注不足的后果。然而，认知行为过程中整合的身体唤醒反应的失败也可能导致一些观察到的缺陷。
Psychophysiological science proposes close interactions between cognitive processes and autonomic responses, yet the consequences of autonomic failure on cognitive functioning have not been documented. This pilot study investigates, for the first time, the cognitive profile of 14 patients with Pure Autonomic Failure (PAF). Each patient was administered a comprehensive battery of neuropsychological tests and neuroimaging investigation. A number of patients (n = 6) presented with cognitive impairment. The two most frequent types of impairment were: deficits of speed and attention, and executive functioning. Impairments of free recall memory, intellectual functioning, nominal and calculation functions were also documented, albeit in a much lower frequency. These cognitive changes were not always associated with white matter abnormalities. We speculate that the cognitive impairments associated with PAF represent consequences of systemic hypotension with cerebral under-perfusion. However, a failure in integrated bodily arousal responses during cognitive behaviours may also contribute to some of the observed deficits.