Involvement of fibrocytes in allergen-induced T cell responses and rhinovirus infections in asthma
Involvement of fibrocytes in allergen-induced T cell responses and rhinovirus infections in asthma
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DOI：
10.1016/j.bbrc.2013.06.099
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发表时间：
2013-08-02
影响因子：
3.1
通讯作者：
Mattoli, Sabrina
中科院分区：
文献类型：
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作者：
Isgro, Mirko;Bianchetti, Lorenza;Mattoli, Sabrina
过敏原暴露和从上呼吸道传播到下呼吸道的鼻病毒感染是哮喘恶化的最常见原因。在疾病加重风险增加的患者中，慢性气道炎症与循环纤维细胞、骨髓来源的具有抗原呈递功能和成纤维细胞样特性的CD34（+）CD45RO（+）CD11b（+）CD13（+）HLA-DR+祖细胞的气道募集相关。这项研究表明，过敏性哮喘患者的过敏原脉冲循环纤维细胞是从自体幼稚和记忆CD4（+）T细胞中主要释放T辅助细胞（Th）2型细胞因子IL-4和IL-5的有效诱导剂。这项研究还提供了证据，过敏性哮喘患者的循环纤维细胞对鼻病毒感染易感。感染的细胞释放大量的促炎细胞因子，产生最少的IFN-α/β。此外，过敏原脉冲的纤维细胞支持鼻病毒的长期复制，并释放大量的促炎细胞因子鼻病毒感染后比unpulsed纤维细胞。因此，纤维细胞可以放大过敏原诱导的Th2细胞驱动的炎症反应，并通过在哮喘气道中作为鼻病毒复制的储存库而促进进一步的炎症。通过这些机制，纤维细胞可能在疾病恶化的激发中发挥重要作用。(C)2013 Elsevier Inc. All rights reserved.
Allergen exposure and rhinovirus infections that propagate from the upper to the lower airways are the most frequent causes of asthma exacerbation. In patients at increased risk of disease exacerbations, chronic airway inflammation is associated with the airway recruitment of circulating fibrocytes, bone marrow-derived CD34(+)CD45RO(+)CD11b(+)CD13(+)HLA-DR+ progenitors that have antigen-presenting function and fibroblast-like properties. This study demonstrates that allergen-pulsed circulating fibrocytes from patients with allergic asthma are potent inducer of the predominant release of the T helper type (Th)2 cytokines IL-4 and IL-5 from autologous naive and memory CD4(+) T cells. This study also provides evidence that circulating fibrocytes from allergic asthmatics are susceptible to rhinovirus infection. Infected cells release high amounts of pro-inflammatory cytokines with minimal production of IFN-alpha/beta. Moreover, allergen-pulsed fibrocytes support prolonged rhinovirus replication and release larger quantities of pro-inflammatory cytokines upon rhinovirus infection than unpulsed fibrocytes. Thus, fibrocytes may amplify allergen-induced, Th2 cell-driven inflammatory responses and promote further inflammation by functioning as a reservoir for rhinovirus replication in asthmatic airways. Through these mechanisms, fibrocytes may play an important role in the provocation of disease exacerbations. (C) 2013 Elsevier Inc. All rights reserved.