Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
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DOI：
10.1016/s0896-6273(01)00505-0
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发表时间：
2001-11-20
期刊：
影响因子：
16.2
通讯作者：
Dickson, BJ
中科院分区：
文献类型：
--
作者：
Keleman, K;Dickson, BJ
Netrins是双功能导向分子，吸引一些轴突，排斥另一些轴突。它们通过DCC和UNCS家族的受体发挥作用。DCC受体与Netrins的吸引和排斥有关。只有在排斥力的作用下，才需要unc5受体。在果蝇中，netrins由中枢神经系统的中线细胞和外围的特定肌肉表达。它们吸引表达DCC家族受体疲乏的连合和运动轴突。在这里，我们报告了果蝇uc5受体的鉴定，并表明它是一种排斥性的Netrin受体，可能有助于运动轴突导引。在中枢神经系统轴突的异位表达可引起中线的短程或长程斥力。短程和长程斥力都需要Netrin功能，但只有远程斥力需要磨损。
Netrins are bifunctional guidance molecules, attracting some axons and repelling others. They act through receptors of the DCC and UNCS families. DCC receptors have been implicated in both attraction and repulsion by Netrins. UNC5 receptors are required only for repulsion. In Drosophila, Netrins are expressed by midline cells of the CNS and by specific muscles in the periphery. They attract commissural and motor axons expressing the DCC family receptor Frazzled. Here we report the identification of the Drosophila Unc5 receptor, and show that it is a repulsive Netrin receptor likely to contribute to motor axon guidance. Ectopic expression of Unc5 on CNS axons can elicit either short- or long-range repulsion from the midline. Both short- and long-range repulsion require Netrin function, but only long-range repulsion requires Frazzled.