A Case-control Study on Risk Factors for Severe Hand, Foot and Mouth Disease.
A Case-control Study on Risk Factors for Severe Hand, Foot and Mouth Disease.
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重症手足口病危险因素的病例对照研究
DOI：
10.1038/srep40282
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发表时间：
2017-01-13
影响因子：
4.6
通讯作者：
Hao Y
中科院分区：
文献类型：
--
作者：
Zhang D;Li R;Zhang W;Li G;Ma Z;Chen X;Du Z;Li Z;Guo P;Lin Z;Lu J;Hao Y
本研究的目的是确定严重手足口病（HFMD）的潜在危险因素。本研究采用病例对照研究方法，对广东省和河南省的459例重症手足口病患者和246例轻型手足口病患者进行研究。收集的数据包括人口统计学特征、临床症状和体征、实验室检查结果和其他因素。单因素分析显示30个与重症相关的因素。进一步的多变量分析显示了四个独立的危险因素：疲劳（p< 0.01，比值比[OR] = 204.7），糖皮质激素的使用（p= 0.03，OR = 10.44），抗抑郁药的使用口部疱疹或溃疡为独立保护因素（P = 0.01，OR = 0.02）。然而，需要更系统的研究和验证，以了解严重手足口病的潜在风险因素。
The objective of this study was to identify potential risk factors for severe hand, foot and mouth disease (HFMD). In this case-control study, 459 severe HFMD patients and 246 mild HFMD patients from Guangdong province and Henan province, China were included. Data comprising demographic characteristics, clinical symptoms and signs, laboratory findings and other factors were collected. Univariate analysis revealed 30 factors associated with severe cases. Further multivariate analysis indicated four independent risk factors: fatigue (p< 0.01, odd ratio [OR] = 204.7), the use of glucocorticoids (p= 0.03, OR = 10.44), the use of dehydrant drugs (p< 0.01, OR = 73.7) and maculopapular rash (p< 0.01, OR = 84.4); and one independent protective factor: herpes or ulcers in mouth (p= 0.01, OR = 0.02). However, more systematic research and validation are needed to understand the underlying risk factors for severe HFMD.