The Effect of Intragastric Balloon on Plasma Ghrelin, Leptin, and Adiponectin Levels in Patients with Morbid Obesity
The Effect of Intragastric Balloon on Plasma Ghrelin, Leptin, and Adiponectin Levels in Patients with Morbid Obesity
复制标题
DOI：
10.1210/jc.2008-1083
复制
发表时间：
2009-05-01
影响因子：
5.8
通讯作者：
Dabrowski, A.
中科院分区：
文献类型：
--
作者：
Konopko-Zubrzycka, M.;Baniukiewicz, A.;Dabrowski, A.
背景：生长素释放肽和瘦素是调节食欲和代谢过程的激素。脂联素在调节葡萄糖和脂质代谢中发挥着重要作用。 目的：本研究的目的是评估接受生物肠胃气球（BIB）、低热量饮食（1500 kcal）和体育锻炼治疗的肥胖受试者血浆生长素释放肽、瘦素和脂联素的水平。设计：21 名体重指数为 47.3 +/- 5.7 的受试者接受 BIB 治疗 6 个月。对照组由 15 名病态肥胖受试者组成，接受低热量饮食和体力锻炼。通过 RIA 测定血浆激素水平。 结果：在 BIB 组中，与对照组（3.2 +/- 6.4 kg）相比，球囊的插入在 6 个月内导致体重显着减少（17.1 +/- 8.0 kg）。 1个月后，ghrelin水平从621.9+/-182.4增加到903.9+/-237pg/ml，此后逐渐下降，在球囊移除后3个月达到起始水平。在同一组中，瘦素水平从 61.3 +/- 36.7 下降至 39.9 +/- 17.5 ng/ml。在对照组中，相应的胃饥饿素和瘦素水平保持相对稳定。在观察期间，BIB 组的脂联素水平保持不变，而对照组则短暂增加。结论：在病态肥胖患者中，BIB 引起的体重减轻与血浆瘦素减少和血浆生长素释放肽短暂升高有关。 BIB 引起的调节能量平衡的激素变化可能会阻止脂联素水平的升高。 (临床内分泌代谢杂志 94: 1644-1649, 2009)
Context: Ghrelin and leptin are hormones regulating appetite and metabolic processes. Adiponectin plays an important role in the modulation of glucose and lipid metabolism.Objective: The objective of the study was to evaluate the levels of plasma ghrelin, leptin, and adiponectin in obese subjects treated with bioenterics intragastric balloon (BIB), low-calorie diet (1500 kcal), and physical exercise.Design: BIB was placed for 6 months in 21 subjects with body mass index 47.3 +/- 5.7. The control group consisted of 15 morbidly obese subjects treated with a low-calorie diet and physical effort. Plasma hormone levels were determined by RIA.Results: In the BIB group, the insertion of the balloon caused a considerable reduction in body mass over a 6-month period (17.1 +/- 8.0 kg) as compared with the control group (3.2 +/- 6.4 kg). After 1 month, the levels of ghrelin increased from 621.9 +/- 182.4 to 903.9 +/- 237 pg/ml and thereafter gradually decreased, reaching the starting level 3 months after the removal of the balloon. In the same group, the levels of leptin decreased from 61.3 +/- 36.7 to 39.9 +/- 17.5 ng/ml. In the control group, the corresponding levels of ghrelin and leptin remained relatively stable. During the observation period, in the BIB group, the levels of adiponectin remained unchanged as opposed to a transient increase noted in the control group.Conclusions: In patients with morbid obesity, weight loss induced by BIB is associated with a decrease in plasma leptin and a transient elevation of plasma ghrelin. It is likely that the changes in hormones regulating the energy balance caused by BIB can prevent an increase in adiponectin level. (J Clin Endocrinol Metab 94: 1644-1649, 2009)