Frequency of five unusual presentations in patients with COVID-19: results of the UMC-19-S1
Frequency of five unusual presentations in patients with COVID-19: results of the UMC-19-S1
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DOI：
10.1017/s0950268820001910
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发表时间：
2020-01-01
影响因子：
4.2
通讯作者：
Gonzalez del Castillo, Juan
中科院分区：
文献类型：
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作者：
Miro, Oscar;Llorens, Pere;Gonzalez del Castillo, Juan
尽管SARS-CoV-19感染具有典型的临床表现，但已报告了具有不寻常表现的孤立病例，其中一些众所周知是由病毒感染引发的。然而，COVID-19中的真实的频率尚不清楚。我们分析了在COVID爆发期间到西班牙50家急诊科（艾德）就诊的63822名COVID患者的数据，在住院前，我们报告了（肌）心包炎的频率（千分之0.71）、脑膜脑炎（千分之0.25），格林-巴利综合征（0.13份/千），急性胰腺炎（0.71份/千）和自发性气胸（0.57份/千）。与一般艾德人群相比，COVID患者更容易发生格林-巴利综合征（比值比（OR）4.55，95%置信区间（CI）2.09-9.90），自发性气胸（OR 1.98，95% CI 1.40-2.79）和（肌）心包炎（OR 1.45，95% CI 1.07-1.97），但较少发生胰腺炎（OR 0.44，95% CI 0.33-0.60）。
Despite SARS-CoV-19 infection has a stereotypical clinical picture, isolated cases with unusual manifestations have been reported, some of them being well-known to be triggered by viral infections. However, the real frequency in COVID-19 is unknown. Analysing data of 63 822 COVID patients attending 50 Spanish emergency department (ED) during the COVID outbreak, before hospitalisation, we report frequencies of (myo)pericarditis (0.71 parts per thousand), meningoencephalitis (0.25 parts per thousand), Guillain-Barre syndrome (0.13 parts per thousand), acute pancreatitis (0.71 parts per thousand) and spontaneous pneumothorax (0.57 parts per thousand). Compared with general ED population, COVID patients developed more frequently Guillain-Barre syndrome (odds ratio (OR) 4.55, 95% confidence interval (CI) 2.09-9.90), spontaneous pneumothorax (OR 1.98, 95% CI 1.40-2.79) and (myo)pericarditis (OR 1.45, 95% CI 1.07-1.97), but less frequently pancreatitis (OR 0.44, 95% CI 0.33-0.60).