GenomeCons: a web server for manipulating multiple genome sequence alignments and their consensus sequences
GenomeCons: a web server for manipulating multiple genome sequence alignments and their consensus sequences
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DOI：
10.1093/bioinformatics/btu803
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发表时间：
2015-04
期刊：
影响因子：
5.8
通讯作者：
Tetsuya Sato;M. Suyama
中科院分区：
文献类型：
--
作者：
Tetsuya Sato;M. Suyama
未标记的基因组序列比对提供了分子生物学过程许多方面的宝贵信息。在这项研究中，我们开发了一个网络服务器 GenomeCons，用于操作多个基因组序列比对及其共识序列，以进行高通量基因组序列分析。该服务器有助于一次对一组基因组间隔的多个基因组序列比对进行目视检查。这允许用户检查这些位点如何随着时间的推移而进化地保留其功能重要性。服务器还报告输入基因组区间的共有序列，可应用于下游分析，例如通过 ChIP-seq 实验确定的区域中常见基序的识别。可用性和实施 GenomeCons 可免费访问：http://bioinfo.sls.kyushu-u.ac.jp/genomecons/ 联系方式 mikita@bioreg.kyushu-u.ac.jp。
UNLABELLED Genome sequence alignments provide valuable information on many aspects of molecular biological processes. In this study, we developed a web server, GenomeCons, for manipulating multiple genome sequence alignments and their consensus sequences for high-throughput genome sequence analyses. This server facilitates the visual inspection of multiple genome sequence alignments for a set of genomic intervals at a time. This allows the user to examine how these sites are evolutionarily conserved over time for their functional importance. The server also reports consensus sequences for the input genomic intervals, which can be applied to downstream analyses such as the identification of common motifs in the regions determined by ChIP-seq experiments. AVAILABILITY AND IMPLEMENTATION GenomeCons is freely accessible at http://bioinfo.sls.kyushu-u.ac.jp/genomecons/ CONTACT mikita@bioreg.kyushu-u.ac.jp.