Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis
Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis
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DOI：
10.1046/j.1365-2133.2001.04078.x
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发表时间：
2001-03-01
影响因子：
10.3
通讯作者：
Andersen, KE
中科院分区：
文献类型：
--
作者：
Mortz, CG;Lauritsen, JM;Andersen, KE
背景 特应性疾病在儿童和青少年中很常见。然而，对于这个年龄段的手部湿疹和过敏性接触性皮炎的流行病学知识却很少。此外，还没有基于人群的研究评估同一青少年群体中特应性疾病以及手部和接触性皮炎的患病率。 目的 评估丹麦欧登塞市青少年中特应性皮炎 (AD)、哮喘、过敏性鼻炎以及手部和接触性皮炎的患病率。 方法 该研究是对 1501 名八年级学生（12-16 岁）进行的横断面研究，包括问卷调查、访谈、临床检查和贴片结果 使用预定义的问卷标准，AD 的终生患病率为 21.3%（女孩 25.7% vs. 男孩 17.0%，P < 0.001）。 AD 的 1 年期患病率为 6.7%，点患病率为 3.6%（Hanifin 和 Rajka 标准）。在访谈中，吸入性过敏的终生患病率估计为 17.7%（过敏性哮喘为 6.9%，过敏性鼻炎为 15.7%）。根据问卷调查，手部湿疹的终生患病率为9.2%，I年患病率为7.3%，点患病率为3.2%，其中以女孩为主。通过终生患病率测量，发现 AD 和吸入性过敏之间以及 AD 和手部湿疹之间存在显着关联。接触过敏的点患病率为 15.2%（女孩 19.4% vs 男孩 10.3%，P < 0.001），目前或既往过敏性接触性皮炎的患病率为 7.2%（女孩 11.3% vs 男孩 2.5%）。接触性过敏以镍（8.6%）和香料混合物（1.8%）最为常见。结论特应性疾病、手部湿疹和过敏性接触性皮炎的患病率较高，且这些疾病之间存在密切相关性。相当多的青少年仍然患有AD，手部湿疹和过敏性接触性皮炎的性别差异也很大。镍过敏和香水过敏是主要的接触过敏。未来，将对这群八年级学生进行跟踪，了解特应性疾病、手部湿疹和接触性皮炎的病程和发展情况。
Background Atopic diseases are common in children and adolescents. However, epidemiological knowledge is sparse for hand eczema and allergic contact dermatitis in this age group. Furthermore, no population-based studies have evaluated the prevalence of atopic diseases and hand and contact dermatitis in the same group of adolescents.Objectives To assess prevalence measures of atopic dermatitis (AD), asthma, allergic rhinitis and hand and contact dermatitis in adolescents in Odense municipality Denmark.Methods The study was carried out as a cross-sectional study among 1501 eighth grade school children (age 12-16 years) and included questionnaire, interview, clinical examination and patch testing.Results The lifetime prevalence of AD was 21.3%.(girls 25.7% vs. boys 17.0%, P < 0.001) using predefined questionnaire criteria. The 1-year period prevalence of AD was 6.7% and the point prevalence 3.6% (Hanifin and Rajka criteria). In the interview the lifetime prevalence of inhalant allergy was estimated as 17.7% (6.9% allergic asthma, 15.7% allergic rhinitis). The lifetime prevalence of hand eczema based on the questionnaire was 9.2%, the I-year period prevalence was 7.3% and the point prevalence 3.2%, with a significant predominance in girls. A significant association was found both between AD and inhalant allergy, and between AD and hand eczema using lifetime prevalence measures. The point prevalence of contact allergy was 15.2% (girls 19.4% vs. boys 10.3%, P < 0.001), and present or past allergic contact dermatitis was found in 7.2% (girls 11.3% vs. boys 2.5%). Contact allergy was most common to nickel (8.6%) and fragrance mix (1.8%).Conclusions High prevalence figures were found for atopic diseases, hand eczema and allergic contact dermatitis, and the diseases were closely associated. A considerable number of adolescents still suffers from AD, and a considerable sex difference was noted for hand eczema and allergic contact dermatitis. Nickel allergy and perfume allergy were the major contact allergies. In the future this cohort of eighth grade school children will be followed up with regard to the course and development of atopic diseases, hand eczema and contact dermatitis.