PENTOBARBITAL, BUT NOT PROPOFOL, PRODUCES PREEMPTIVE ANALGESIA IN THE RAT FORMALIN MODEL
PENTOBARBITAL, BUT NOT PROPOFOL, PRODUCES PREEMPTIVE ANALGESIA IN THE RAT FORMALIN MODEL
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DOI：
10.1093/bja/72.6.662
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发表时间：
1994-06-01
影响因子：
9.8
通讯作者：
CROSBY, G
中科院分区：
文献类型：
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作者：
GOTO, T;MAROTA, JJA;CROSBY, G
将福尔马林注射到大鼠的后爪中诱导疼痛相关行为中的双相反应，使得阶段I期间的C纤维激活触发以较长持续阶段2为特征的中枢致敏状态。由于抑制性神经递质γ-氨基丁酸（GABA）可能参与了伤害性信息的加工，我们假设戊巴比妥和异丙酚，iv。具有已知GABA（A）激动剂特性的麻醉剂会干扰中枢致敏的发展，从而改变2相痛觉过敏反应。戊巴比妥静脉给药。在注射福尔马林之前给药，即使动物已经从麻醉中恢复，也会产生对2期的剂量依赖性抑制，而在1期消退之后给药时，其效果明显较小。印防己毒素是一种GABA（A）拮抗剂，可逆转戊巴比妥对2相疼痛行为的影响，但其本身是一种温和的镇痛剂。相反，丙泊酚对福尔马林诱导的2相疼痛行为没有影响。因此，我们得出结论，戊巴比妥，而不是异丙酚，产生先发制人的镇痛在这个模型中，可能是通过抑制伤害性刺激诱导的中枢敏化通过激活GABA（A）受体。
Injection of formalin into the hindpaw of a rat induces a biphasic response in pain-related behaviours, such that C-fibre activation during phase I triggers a state of central sensitization characterized by a longer lasting phase 2. As the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) may participate in processing of nociceptive inputs, we hypothesized that pentobarbitone and propofol, iv. anaesthetics with known GABA(A) agonist properties, would interfere with development of central sensitization and thereby modify the phase 2 hyperalgesic response. Pentobarbitone administered i. v. before injection of formalin produced dose-dependent suppression of phase 2, even though animals had recovered from anaesthesia, whereas it had substantially less effect when given after phase 1 had resolved. Picrotoxin, a GABA(A) antagonist, reversed the effect of pentobarbitone on phase 2 pain behaviour but was itself a mild analgesic. in contrast, propofol had no effect on phase 2 formalin-induced pain behaviour. Thus we conclude that pentobarbitone, but not propofol, produced pre-emptive analgesia in this model, presumably by suppressing noxious stimulation-induced central sensitization via activation of GABA(A) receptors.