The endocannabinoid system and extinction learning
The endocannabinoid system and extinction learning
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DOI：
10.1007/s12035-007-8004-x
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发表时间：
2007-08-01
影响因子：
5.1
通讯作者：
Lutz, Beat
中科院分区：
文献类型：
--
作者：
Lutz, Beat
内源性大麻素系统已成为一种多功能的神经调节系统，涉及过多的生理和病理生理过程。大麻素受体1型（CB 1受体）和内源性大麻素广泛分布于大脑中。它们在学习和记忆中的作用已经有了很好的记录，在各种记忆测试中使用啮齿动物。取决于测试，内源性大麻素系统在记忆的获得和/或消失中是必需的。特别是，CB 1受体介导的信号的激活是集中参与的行为适应后，获得厌恶性记忆的便利。由于几种人类精神疾病，如恐惧症，广泛性焦虑症和创伤后应激障碍（PTSD）似乎涉及异常的记忆处理和对改变的环境条件的适应性受损，因此内源性大麻素系统可能是治疗这些疾病的有价值的治疗靶点的希望已经被点燃。本文综述了内源性大麻素系统在消退学习调节中的作用。
The endocannabinoid system has emerged as a versatile neuromodulatory system, implicated in a plethora of physiological and pathophysiological processes. Cannabinoid receptor type 1 (CB1 receptor) and endocannabinoids are widely distributed in the brain. Their roles in learning and memory have been well documented, using rodents in various memory tests. Depending on the test, the endocannabinoid system is required in the acquisition and/or extinction of memory. In particular, the activation of CB1 receptor-mediated signaling is centrally involved in the facilitation of behavioral adaptation after the acquisition of aversive memories. As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders. This review summarizes the current data on the role of the endocannabinoid system in the modulation of extinction learning.