A possible melanoma discrimination index based on hyperspectral data: a pilot study
A possible melanoma discrimination index based on hyperspectral data: a pilot study
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DOI：
10.1111/j.1600-0846.2011.00571.x
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发表时间：
2012-08-01
影响因子：
2.2
通讯作者：
Sota, Takayuki
中科院分区：
文献类型：
--
作者：
Nagaoka, Takashi;Nakamura, Atsushi;Sota, Takayuki
背景：早期发现和适当切除恶性黑色素瘤（MM）原发病灶对于减少黑色素瘤相关死亡至关重要。为了支持黑色素瘤的早期发现，自动化黑色素瘤筛查系统已经被广泛研究和开发。在本文中，我们提出了一种高光谱黑色素瘤筛查系统，并提出了一种可能的黑色素瘤鉴别指数，该指数来源于皮肤色素分子的特征，两者都是来自高光谱数据（HSD）。方法该指数表示每个病变的无序性，包括基于从每个病变获得的光谱信息的变化的颜色变化。研究了该指标在5例黑色素瘤（41组HSD）、1例Spitz痣（13组HSD）、10例脂溢性角化病（78组HSD）、3例基底细胞癌（16组HSD）和9例黑素细胞痣（21组HSD）中对黑素瘤与其他色素性皮肤病变的鉴别性能。这些患者和志愿者均为日本人。结果该指标反映了病变的无序性，对黑素瘤的识别灵敏度为90%，特异性为84%，再替代时的受者工作特征曲线下面积为0.93。结论提出了一种基于HSD的分子色素水平的客观黑色素瘤鉴别指数，并对其性能进行了评价。该指数在区分MM和非黑色素瘤方面非常成功，尽管统计群体很小。
Background Early detection and proper excision of the primary lesions of malignant melanoma (MM) are crucial for reducing melanoma-related deaths. To support the early detection of melanoma, automated melanoma screening systems have been extensively studied and developed. In this article, we present a hyperspectral melanoma screening system and propose a possible melanoma discrimination index derived from the characteristics of the pigment molecules in the skin, both of which have been derived from hyperspectral data (HSD). Methods The index expresses the disordered nature of each lesion including variegation in color based on variation in spectral information obtained from each lesion. Performance of the index in discriminating melanomas from other pigmented skin lesions has been studied in five cases of melanoma (41 HSD sets), one case of Spitz nevus (13 HSD sets), 10 cases of seborrheic keratosis (78 HSD sets), three cases of basal cell carcinoma (16 HSD sets), and nine cases of melanocytic nevus (21 HSD sets), obtained from patients and volunteers, all of whom were Japanese. Results Performance of the index, which reflects the disordered nature of a lesion, discriminates melanomas with a sensitivity of 90%, a specificity of 84%, and an area under the receiver operating characteristic curve of 0.93, on resubstitution. Conclusion An objective melanoma discrimination index at a molecular pigmentary level, derived from HSD, has been proposed, and its performance evaluated. This index was highly successful in discriminating MM from non-melanoma, although the statistical population was small.