A comparison of the effects of desflurane and isoflurane on arterial oxygenation during one-lung ventilation
A comparison of the effects of desflurane and isoflurane on arterial oxygenation during one-lung ventilation
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DOI：
10.1046/j.1365-2044.2000.055002167.x
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发表时间：
2000-02-01
期刊：
影响因子：
10.7
通讯作者：
Pennefather, SH
中科院分区：
文献类型：
--
作者：
Wang, JYY;Russell, GN;Pennefather, SH
在一项随机前瞻性交叉研究中，我们比较了地氟烷和异氟烷在单肺麻醉期间对动脉氧合、心率和平均动脉压的影响。将30例计划行食管胃切除术的患者随机分为两组。一组15例患者从诱导开始接受地氟烷，潮气末浓度为6%的氧气，直到侧卧位开胸单肺通气30分钟结束。随后，在接下来的30分钟单肺通气中，使用异氟烷至潮气末浓度为1.1%的氧气。另一组15名患者按相反顺序接受两种麻醉剂。我们发现两种吸入剂在动脉氧合、心率或平均动脉压方面无显著差异。在10例肺动脉导管患者的亚组中，我们发现混合静脉饱和度、衍生分流或心输出量无显著差异。我们的结论是，在单肺通气期间，地氟烷和异氟烷之间的选择不会显着影响动脉氧合。
In a randomised prospective cross-over study, we compared the effects of desflurane and isoflurane on arterial oxygenation, heart rate and mean arterial pressure during one-lung anaesthesia. Thirty patients scheduled for oesophagogastrectomy were randomly assigned to one of two groups. One group of 15 patients received desflurane to an end-tidal concentration of 6% in oxygen from induction until the end of 30 min of open chest one-lung ventilation in the lateral position. This was followed by isoflurane to an end-tidal concentration of 1.1% in oxygen for the next 30 min of one-lung ventilation. The other group of 15 patients received the two anaesthetic agents in the reverse order. We found no significant difference in arterial oxygenation, heart rate or mean arterial pressure between the two inhalational agents. In the subgroup of 10 patients with pulmonary artery catheters, we found no significant differences in mixed venous saturation, derived shunt or cardiac output. We conclude that during one-lung ventilation, the choice between desflurane and isoflurane does not significantly influence arterial oxygenation.