Postnatal neurophysiologic effects of prenatal X-irradiation.
Postnatal neurophysiologic effects of prenatal X-irradiation.
复制标题
产前 X 射线照射的产后神经生理学影响。
DOI：
10.1080/09553009514550271
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发表时间：
1995
影响因子：
2.6
通讯作者：
Brent,RL
中科院分区：
文献类型：
--
作者：
Jensh,RP;Eisenman,LM;Brent,RL
本实验观察了孕17天Wistar大鼠经2·0戈伊X线照射和假照射后子宫内照射的组织学和神经生理学效应。对234名新生儿进行了四项选定生理指标的出现年龄和五项选定反射的获得年龄的监测。使用选定的行为测试对后代进行评估。每周监测产后生长。对选定的后代进行尸检，以确定是否存在形态学中枢神经系统改变。结果表明，大鼠胚胎期接受2·0戈伊X射线照射，可引起成年期机体的永久性改变，包括不可恢复的生长发育迟缓、脑形态学改变如小头畸形、小脑皮质细胞形态异常、海马细胞结构改变、选择性反射的获得减少等。选定的生理标志物的外观改变;以及成年人测试表现的变化，表明受辐射后代中存在显著的活动过度。在此期间暴露于X射线会导致行为和形态的改变，这种改变会持续一生。
Histological and neurophysiological effects ofin uteroirradiation were examined following exposure of pregnant Wistar rat to 2·0 Gy X-irradiation or sham-irradiated on the 17th day of gestation. The 234 newborns were monitored for the age of appearance of four selected physiologic markers and the age of acquisition of five selected reflexes. Offspring were evaluated as young adults using selected behavioural tests. Postnatal growth was monitored weekly. Selected offspring were autopsied to determine the presence of morphologic central nervous system alterations. The results indicated that 2·0 Gy X-irradiation during the foetal period in rat gestation caused permanent alterations in the mature adult organism, which include non-recuperable growth retardation, morphologic changes in the brain such as microcephaly, abnormal cerebellar cortical cellular patterns, and alterations in the cell architecture of the hippocampus; diminished attainment of selected reflexes; alterations in the appearance of selected physiologic markers; and changes in adult test performance indicating significant hyperactivity among the irradiated offspring. Such exposure to X-irradiation during this period results in behavioural and morphologic alterations, which persist throughout life.