EVIDENCE THAT HISTIDINE IS AN ESSENTIAL AMINO-ACID IN NORMAL AND CHRONICALLY UREMIC MAN
EVIDENCE THAT HISTIDINE IS AN ESSENTIAL AMINO-ACID IN NORMAL AND CHRONICALLY UREMIC MAN
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DOI：
10.1172/jci108016
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发表时间：
1975-01-01
影响因子：
15.9
通讯作者：
SWENDSEID, ME
中科院分区：
文献类型：
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作者：
KOPPLE, JD;SWENDSEID, ME
在四名正常人和三名慢性尿毒症男性中研究了对饮食组氨酸的需求。受试者生活在一个代谢单位中，按以下顺序喂食三种等氮饮食：40 g蛋白质饮食（28 ± SD 8天），缺乏组氨酸的半合成氨基酸饮食（35 ± 2天）和含有组氨酸的氨基酸饮食（31 ± 5天）。随着组氨酸缺乏饮食的摄入，氮平衡逐渐变为负值，6名受试者的血清白蛋白降低。血浆组氨酸下降了82 ± 6%;肌肉组氨酸下降了62 ± 19%;红细胞压积下降了25 ± 9%;血清铁上升。受试者感到不适，在5例病例中出现了由细鳞、皮肤干燥和轻度红斑组成的皮肤病变。给予富含组胺酸的饮食后，六名受试者的氮平衡变为正值;五名受试者的血清白蛋白增加;血浆和肌肉组胺酸升高;血清铁突然下降;随之而来的是网织红细胞增多症;红细胞压积上升。临床症状及皮损消失。这些观察结果表明，组氨酸是正常人和慢性尿毒症患者的必需氨基酸，饮食中缺乏组氨酸与正常红细胞生成障碍有关。
The requirement for dietary histidine was investigated in four normal and three chronically uremic men. Subjects lived in a metabolic unit where they were fed three isonitrogenous diets in the following order: a 40-g protein diet (28 plus or minus SD 8 days), a semi-synthetic amino acid diet deficient in histidine (35 plus or minus 2 days), and an amino acid diet which contained histidine (31 plus or minus 5 days). With ingestion of the histidine-deficient diet, nitrogen balance gradually became negative, and serum albumin decreased in six subjects. Plasma histidine fell by 82 plus or minus 6 per cent; muscle histidine decreased by 62 plus or minus 19 per cent; the hematocrit fell by 25 plus or minus 9 per cent; and serum iron rose. Subjects felt unwell, and in five cases a skin lesion consisting of fine scales, dry skin, and mild erythema developed. After administration of the histidine-repletion diet, nitrogen balance became positive in six subjects; serum albumin increased in five cases; plasma and muscle histidine rose; serum iron fell abruptly; a reticulocytosis ensued; and the hematocrit rose. The clinical symptoms and skin lesions disappeared. These observations indicate that histidine is an essential amino acid in normal and chronically uremic man. The absence of dietary histidine is associated with failure of normal erythropoiesis.