Comparison of the time course of atopic dermatitis from birth to 19 years old among generations of patients in Japan
Comparison of the time course of atopic dermatitis from birth to 19 years old among generations of patients in Japan
复制标题
DOI：
10.1111/1346-8138.16085
复制
发表时间：
2021-07-27
影响因子：
3.1
通讯作者：
Hide, Michihiro
中科院分区：
文献类型：
--
作者：
Tanaka, Akio;Morioke, Satoshi;Hide, Michihiro
特应性皮炎（AD）主要发生在儿童早期，并随着年龄的增长而消退。然而，青春期前后其严重程度的时间进程在患者之间差异很大。为了调查成年 AD 患者从出生到 19 岁的疾病严重程度的过程，我们对 3090 名被诊断患有 AD 的日本成年受试者进行了一项全国性的网络调查，使用问卷从 10 个 AD 严重程度的过程中选择一个与自己最相似的模式。 20多岁和30多岁年龄组的患者倾向于选择“逐渐好转”或“12岁时好转”选项，但40多岁或以上年龄组的患者倾向于选择“12岁至19岁之间加重”选项。随着年龄的增长，选择“20岁以上出现AD”的人也随之增加。这项调查显示，从出生到 19 岁，AD 严重程度的时间进程因本研究的目标世代而异。据推测，在日本，影响 AD 自然史的后天因素在过去 50 年中发生了变化。
Atopic dermatitis (AD) mostly develops in early childhood and tends to resolve with age. However, its time course in severity before and after adolescence varies widely among patients. To investigate the course of disease severity from birth to 19 years old of adult patients with AD, we conducted a nationwide Web-based survey of 3090 Japanese adult subjects diagnosed with AD, using a questionnaire to choose a pattern that most resembled their own out of 10 courses of AD severity. Patients in the 20s and 30s age groups tended to choose the option "gradually improved" or "improved by the age of 12", but patients in the 40s or older age group tended to choose the option "aggravation between the age of 12 and 19". Those who chose "AD development at age 20 or older" increased as the generation was older. This survey revealed that the time course of AD severity from birth to 19 years old varies depending on the generation targeted in this study. It is presumed that the acquired factors affecting the natural history of AD have changed over the past 50 years in Japan.