Eph receptors and ephrins engage in cellular cannibalism.

Eph receptors and ephrins engage in cellular cannibalism.
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Eph 受体和肝配蛋白参与细胞自相残杀。

DOI:
10.1083/jcb.201908074
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发表时间:
2019
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Pasquale,ElenaB
Pasquale,ElenaB
中科院分区:
--
文献类型:
--
作者:
Pasquale,ElenaB

文献摘要

相似文献

Eph受体结合邻近细胞上的肝配蛋白,寡聚成粘附复合物,募集信号分子。执行他们的标志性排斥程序,然后产生拉力,使一个细胞吞噬另一个细胞的一部分。Gong等人的新机制见解(2019. J. Cell Biol. https://doi.org/10.1083/jcb.201901032)将该过程定义为“细胞同类相食”的一种形式。
Eph receptors bind ephrins on neighboring cells, oligomerizing into adhesive complexes that recruit signaling molecules. Execution of their signature repulsive program then generates pulling forces, enabling a cell to engulf a piece of another cell. New mechanistic insights by Gong et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201901032) define this process as a form of “cellular cannibalism.”