Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells.
Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells.
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DOI：
10.1111/j.1582-4934.2010.01081.x
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发表时间：
2010-05
影响因子：
5.3
通讯作者：
Doevendans PA
中科院分区：
文献类型：
--
作者：
Vrijsen KR;Sluijter JP;Schuchardt MW;van Balkom BW;Noort WA;Chamuleau SA;Doevendans PA
心肌梗塞导致心力衰竭的病人需要心脏移植。不幸的是，供体心脏的数量非常少，因此新的治疗方法是研究的主题。心肌梗死后的细胞移植治疗是一种非常有前途的策略，可以用存活的心肌细胞、平滑肌细胞和内皮细胞代替死亡的心肌，从而减少瘢痕形成，提高心脏功能。尽管有很好的结果，在短期内导致梗死面积减少和心功能改善，但只有少数细胞在缺血环境中存活并保留在心脏中，从而使长期影响最小化。虽然新的毛细血管和心肌细胞在梗死区周围形成，但在心肌梗死数月后，只有一小部分移植细胞能被检测到。这表明细胞移植刺激了心脏的内源性再生能力，这是由祖细胞释放生长因子、细胞因子和其他旁分泌分子引起的，即所谓的旁分泌假说。在这里，我们专注于旁分泌信号的一个相对新的组成部分，即外泌体。我们对源自心脏祖细胞的外泌体的释放和功能感兴趣，并研究了它们对内皮细胞迁移能力的影响。
Patients suffering from heart failure as a result of myocardial infarction are in need of heart transplantation. Unfortunately the number of donor hearts is very low and therefore new therapies are subject of investigation. Cell transplantation therapy upon myocardial infarction is a very promising strategy to replace the dead myocardium with viable cardiomyocytes, smooth muscle cells and endothelial cells, thereby reducing scarring and improving cardiac performance. Despite promising results, resulting in reduced infarct size and improved cardiac function on short term, only a few cells survive the ischemic milieu and are retained in the heart, thereby minimizing long-term effects. Although new capillaries and cardiomyocytes are formed around the infarcted area, only a small percentage of the transplanted cells can be detected months after myocardial infarction. This suggests the stimulation of an endogenous regenerative capacity of the heart upon cell transplantation, resulting from release of growth factor, cytokine and other paracrine molecules by the progenitor cells – the so-called paracrine hypothesis. Here, we focus on a relative new component of paracrine signalling, i.e. exosomes. We are interested in the release and function of exosomes derived from cardiac progenitor cells and studied their effects on the migratory capacity of endothelial cells.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
Stetler-Stevenson, WG