Generator mechanisms of giant somatosensory evoked potentials in cortical reflex myoclonus.
Generator mechanisms of giant somatosensory evoked potentials in cortical reflex myoclonus.
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皮质反射性肌阵挛巨体感诱发电位的发生器机制。
DOI：
10.1093/brain/110.5.1359
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Hiroshi Shibasaki
中科院分区：
文献类型：
--
作者：
R. Kakigi;Hiroshi Shibasaki
为探讨巨大皮层诱发电位的发生机制，对5例皮层反射性肌阵挛患者进行了不同刺激方式（包括神经干电刺激、手指电刺激和机械刺激）的头皮体感诱发电位（SEP）地形图研究。刺激正中神经诱发的SEP，不仅中央区和顶叶的P25和N34成分明显增大，额叶的N25成分也明显增大。他们的头皮分布与正常人没有显着差异。P25和N25，但不是N34，被施加到手的干扰触觉刺激大大衰减。对应于P25，N25和N34的组件后，数字神经的电刺激以及手指的机械刺激也非常大，并显示出头皮分布类似于正中神经SEP。因此，可以得出结论，巨大的皮质SEP的皮质反射肌阵挛产生在这些地区的初级感觉皮层产生正常的SEP，在响应输入，至少部分地，从皮肤传入的基础上，一个非常增强的皮层兴奋性。
In order to clarify the generator mechanisms for giant cortical evoked potentials, scalp topographies of somatosensory evoked potentials (SEPs) following various types of stimulation, including electrical nerve trunk and finger stimulation and mechanical stimulation, were investigated in 5 patients with cortical reflex myoclonus. For SEPs evoked by median nerve stimulation, not only the P25 and N34 components in central and parietal regions but also N25 in the frontal region were markedly enlarged in each patient. Their scalp distributions were not significantly different from those of normal subjects. P25 and N25, but not N34, were considerably attenuated by interfering tactile stimulation applied to the hand. The components corresponding to P25, N25 and N34 following electrical stimulation of the digital nerves as well as mechanical stimulation of the finger were also remarkably large and showed scalp distributions similar to those for median nerve SEPs. It is therefore concluded that the giant cortical SEPs of cortical reflex myoclonus are generated in those areas of the primary sensory cortex which generate normal SEPs, in response to an input, at least in part, from cutaneous afferents on the basis of an extremely enhanced cortical excitability.