Auditory space-time receptive field dynamics revealed by spherical white-noise analysis
Auditory space-time receptive field dynamics revealed by spherical white-noise analysis
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DOI：
10.1523/jneurosci.21-12-04408.2001
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发表时间：
2001-06-15
影响因子：
5.3
通讯作者：
Brugge, JF
中科院分区：
文献类型：
--
作者：
Jenison, RL;Schunpp, JWH;Brugge, JF
许多研究已经调查了猫的听觉皮层神经元的空间敏感性，但可能的动态特性的空间感受野已在很大程度上被忽视。考虑到相当数量的证据表明，初级听觉场在负责感知声源位置的神经通路中，对早期观察的频谱时间感受野的逻辑扩展，它表征了频率调谐的动态，是使用声源方向而不是声音频率来研究空间调谐随时间的演变。本研究的目的是使用一种新的方法描述听觉时空感受野动态的交叉相关技术和白噪声分析的基础上，在球形听觉空间。这导致了听觉感受野在两个球形空间维度（方位角和仰角）加上第三个时间维度上的表征。进一步的分析表明，听觉皮层神经元的空间感受野与视觉系统的感受野一样，不是静态的，而是具有明显的时间动态性。例如，这可能导致神经元对移动听觉声源的方向和速度具有选择性。我们的研究结果表明，类似于14%的铝神经元证据显着的时空相互作用（不可分离性）。
Numerous studies have investigated the spatial sensitivity of cat auditory cortical neurons, but possible dynamic properties of the spatial receptive fields have been largely ignored. Given the considerable amount of evidence that implicates the primary auditory field in the neural pathways responsible for the perception of sound source location, a logical extension to earlier observations of spectrotemporal receptive fields, which characterize the dynamics of frequency tuning, is a description that uses sound source direction, rather than sound frequency, to examine the evolution of spatial tuning over time. The object of this study was to describe auditory space-time receptive field dynamics using a new method based on cross-correlational techniques and white-noise analysis in spherical auditory space. This resulted in a characterization of auditory receptive fields in two spherical dimensions of space (azimuth and elevation) plus a third dimension of time. Further analysis has revealed that spatial receptive fields of neurons in auditory cortex, like those in the visual system, are not static but can exhibit marked temporal dynamics. This might result, for example, in a neuron becoming selective for the direction and speed of moving auditory sound sources. Our results show that similar to 14% of Al neurons evidence significant space-time interaction (inseparability).