Modification of neuron numbers in the visual system of the rat
Modification of neuron numbers in the visual system of the rat
复制标题
大鼠视觉系统神经元数量的改变
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
M. Murray
中科院分区：
文献类型：
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作者：
T. J. Cunningham;Chris Huddelston;M. Murray
出生时单侧大脑后皮质损伤后，同侧外侧膝状体背侧核在96小时内消失。剩下的几个视觉中枢可能变形、萎缩或肥大。最后一个例子是同侧视束核（NOT）和上级丘（SC）的浅层，通常显示体积增加。为了确定这两个区域神经元数量的变化，我们在特定的胚胎日将大鼠暴露于3 H-胸苷。这些大鼠中的一些在出生当天接受后部皮质损伤，其他大鼠作为对照。在胚胎第13天和第14天暴露于3 H-胸苷的成年大鼠的计数显示，病变侧的NOT和SC中标记神经元的数量显著增加。用银变性法测定出生时后部病变大鼠的视网膜投射。非典型的视觉投射被发现的外侧后核和非病变侧。我们的结论是，重新分配后，早期破坏的背外侧膝状体核的视神经侧支，以增加神经元数量的NOT和SC。因此，目前的研究结果是可比的结果在非哺乳动物移植后的额外的外周器官。
After unilateral lesions of the posterior cerebral cortex at birth, the ipsilateral dorsal lateral geniculate nucleus disappears within 96 hours. Several of the remaining visual centers may be distorted, atrophic or hypertrophic. Examples of the last are the ipsilateral nucleus of the optic tract (NOT) and superficial layers of the superior colliculus (SC), which usually show a volume increase. In order to determine changes in neuron numbers in these two regions, we exposed rats to 3H‐thymidine on specific embryonic days. Some of these rats received posterior cortical lesions on the day of birth and others served as controls. Counts from adult rats exposed to 3H‐thymidine on embryonic days 13 and 14 reveal a significant increase in the number of labeled neurons in both the NOT and SC on the side of the lesion. The retinal projections in rats with posterior lesions at birth were determined by the application of silver degeneration methods after eye removal. Atypical optic projections are found to the lateral posterior nucleus and the NOT on the side of the lesion. We conclude that the redistribution of optic collaterals after early destruction of the dorsal lateral geniculate nucleus serves to increase neuron numbers in the NOT and SC. Therefore, the present findings are comparable to the results in nonmammals after transplantation of additional peripheral organs.