Protein S-Nitrosylation in plants: Current progresses and challenges
Protein S-Nitrosylation in plants: Current progresses and challenges
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DOI：
10.1111/jipb.12780
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发表时间：
2019-12-01
影响因子：
11.4
通讯作者：
Zuo, Jianru
中科院分区：
文献类型：
--
作者：
Feng, Jian;Chen, Lichao;Zuo, Jianru
一氧化氮（NO）是调节所有生物体中多种生物过程的重要信号分子。 NO 的主要生理功能是通过蛋白质 S-亚硝基化来执行的，这是一种基于氧化还原的翻译后修饰，通过将 NO 分子共价添加到靶蛋白的反应性半胱氨酸硫醇上来实现。 S-亚硝基化是一种进化上保守的机制，调节细胞信号传导的多个方面。在过去的十年中，植物中 S-亚硝基化蛋白的功能表征取得了重大进展。新的证据表明蛋白质 S-亚硝基化普遍参与植物发育和胁迫反应的调节。在这里，我们回顾了目前对植物各种生物过程中蛋白质 S-亚硝基化调节机制的理解，并强调了该领域的关键挑战。
Nitric oxide (NO) is an important signaling molecule regulating diverse biological processes in all living organisms. A major physiological function of NO is executed via protein S-nitrosylation, a redox-based posttranslational modification by covalently adding a NO molecule to a reactive cysteine thiol of a target protein. S-nitrosylation is an evolutionarily conserved mechanism modulating multiple aspects of cellular signaling. During the past decade, significant progress has been made in functional characterization of S-nitrosylated proteins in plants. Emerging evidence indicates that protein S-nitrosylation is ubiquitously involved in the regulation of plant development and stress responses. Here we review current understanding on the regulatory mechanisms of protein S-nitrosylation in various biological processes in plants and highlight key challenges in this field.