Extending the effects of spike-timing-dependent plasticity to behavioral timescales
Extending the effects of spike-timing-dependent plasticity to behavioral timescales
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DOI：
10.1073/pnas.0600676103
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发表时间：
2006-06-06
影响因子：
11.1
通讯作者：
Abbott, L. F.
中科院分区：
文献类型：
--
作者：
Drew, Patrick J.;Abbott, L. F.
突触时序可塑性(STDP)引起的突触强度的活动依赖性改变对突触前和突触后放电之间在几十毫秒的时间尺度上的相关性很敏感。行为任务中通常遇到的时间关联涉及数秒量级的时间。为了将这种时间关联的学习与STDP联系起来，我们必须解释时间尺度上的这种巨大差异。我们表明，如果相关的刺激产生在时间上适当变化的持续反应，突触和行为时标之间的差距可以被弥合。以这种方式激发的神经元之间的突触可以被STDP以一种依赖于相隔几秒的事件的时间顺序的方式进行修改，即使潜在的可塑性具有小得多的时间窗口。
Activity-dependent modification of synaptic strengths due tospike-timing-dependent plasticity (STDP) is sensitive to correlations between pre- and postsynaptic firing over timescales of tens of milliseconds. Temporal associations typically encountered in behavioral tasks involve times on the order of seconds. To relate the learning of such temporal associations to STDP, we must account for this large discrepancy in timescales. We show that the gap between synaptic and behavioral timescales can be bridged if the stimuli being associated generate sustained responses that vary appropriately in time. Synapses between neurons that fire this way can be modified by STDP in a manner that depends on the temporal ordering of events separated by several seconds even though the underlying plasticity has a much smaller temporal window.