RESPIRATORY STATUS AND ALLERGY AFTER BRONCHIOLITIS
RESPIRATORY STATUS AND ALLERGY AFTER BRONCHIOLITIS
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DOI：
10.1136/adc.67.4.482
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发表时间：
1992-04-01
影响因子：
5.2
通讯作者：
MILNER, AD
中科院分区：
文献类型：
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作者：
MURRAY, M;WEBB, MSC;MILNER, AD
作为一项长期前瞻性研究的一部分，73名婴儿时期因病毒性毛细支气管炎入院的儿童在5.5年后被回顾，并与仔细匹配的对照组进行比较。在毛细支气管炎组中，包括喘息在内的呼吸道症状显著增加(42.5%比15.0%，相对危险度=2.8)。虽然指标组的家族特应性没有明显增加，但个人特应性更常见。然而，与无症状的毛细支气管炎患者相比，有症状的毛细支气管炎患者个人过敏症的发生率并不显著，因此不能解释该队列中毛细支气管炎后喘息的高患病率。此外，在逐步Logistic回归模型中，在调整了包括特应性在内的潜在混杂变量后，毛细支气管炎仍然是喘息的重要预测因素。指标组的支气管对组胺的反应性显著增强。然而，阳性试验与喘息之间没有明显的关系，在对照组中有很高的阳性反应率。
As part of a long term prospective study, 73 children who had been admitted to hospital with viral bronchiolitis as infants, were reviewed 5.5 years later and compared with a carefully matched control group. In the postbronchiolitis group, there was a highly significant increase in respiratory symptoms including wheezing (42.5% v 15.0%, relative risk = 2.8).Although atopy in the family was not significantly increased in the index group, personal atopy was more prevalent. However, personal atopy was not significantly more prevalent in the symptomatic postbronchiolitis, compared with those who were symptom free, and so did not account for the high prevalence of postbronchiolitis wheezing in this cohort. In addition, in a stepwise logistic regressional model, bronchiolitis remained a significant predictor of wheezing after adjusting for potential confounding variables, including atopy. Bronchial responsiveness to histamine was significantly increased in the index group. However, no significant relationship of positive tests to wheezing could be demonstrated, and a high rate of positive responses was noted in the controls.