Procalcitonin as a diagnostic marker of ventilator-associated pneumonia in cardiac surgery patients
Procalcitonin as a diagnostic marker of ventilator-associated pneumonia in cardiac surgery patients
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DOI：
10.3892/etm.2015.2175
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发表时间：
2015-03-01
影响因子：
2.7
通讯作者：
Zhou, Xinmin
中科院分区：
文献类型：
--
作者：
Jiao, Jia;Wang, Min;Zhou, Xinmin
本研究的目的是评估降钙素原（PCT）是否可用作心脏手术患者呼吸机相关性肺炎（VAP）的诊断标志物。在2012年1月至2013年6月期间，共招募了92名患者，并将其分为非雅普组（59名患者）和雅普组（33名患者）。记录患者的术前和术后特征。采用电化学发光免疫分析法测定血清PCT、白细胞介素（IL）-6和C反应蛋白（CRP）水平。随后，构建PCT、IL-6和CRP水平的受试者工作特征曲线。此外，分析了雅普患者的序贯器官衰竭评估（SOFA）评分与血清PCT、IL-6和CRP水平之间的关系。非雅普患者和雅普患者的术后并发症发生率无统计学显著差异。然而，与非雅普组相比，雅普组的SOFA评分（第1天和第7天）、在重症监护室的停留时间和机械通气时间均显著增加（P
The aim of the present study was to assess whether procalcitonin (PCT) can be used as a diagnostic marker for ventilator-associated pneumonia (VAP) in cardiac surgery patients. Between January 2012 and June 2013, a total of 92 patients were recruited and divided into non-YAP (59 patients) and YAP (33 patients) groups. The preoperative and postoperative characteristics of the patients were recorded. Serum levels of PCT, interleukin (IL)-6 and C-reactive protein (CRP) were measured using an electrochemiluminescence immunoassay. Subsequently, receiver operating characteristic curves of the PCT, IL-6 and CRP levels were constructed. In addition, associations between the sequential organ failure assessment (SOFA) scores and the serum levels of PCT, IL-6 and CRP in the YAP patients were analyzed. No statistically significant difference was observed between the non-YAP and YAP patients in the occurrence of postoperative complications. However, the SOFA scores (days 1 and 7), the duration of stay in the intensive care unit and the mechanical ventilation time were all significantly higher in the YAP group when compared with the non-YAP group (P