Dissociating effects of cocaine and d-amphetamine on dopamine and serotonin in the perirhinal, entorhinal, and prefrontal cortex of freely moving rats.
Dissociating effects of cocaine and d-amphetamine on dopamine and serotonin in the perirhinal, entorhinal, and prefrontal cortex of freely moving rats.
复制标题
可卡因和 d-苯丙胺对自由活动大鼠的鼻周、内嗅和前额皮质中的多巴胺和血清素的解离作用。
DOI：
10.1007/s00213-007-0791-2
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发表时间：
2007
影响因子：
3.4
通讯作者：
Müller,CP
中科院分区：
文献类型：
--
作者：
Pum,M;Carey,RJ;Huston,JP;Müller,CP
对人类的神经影像学研究表明，大脑皮层对精神兴奋剂药物的反应是广泛的激活。然而，在这方面，这些脑活动的神经化学性质没有被表征。本研究的目的是调查可卡因和d-安非他明对海马网络皮质区中的多巴胺（DA）和5-羟色胺（5-HT）的影响，并与前额叶皮质（PFC）进行比较。材料和方法我们在行为大鼠中进行体内微透析实验，测量嗅周皮质（PRC）中的DA和5-HT，内嗅皮层（EC）和PFC，在应用可卡因（0、5、10、20 mg/kg; i. p.）左旋苯丙胺（0、0.5、1.0、2.5 mg/kg; i. p.）结果多巴胺和右旋苯丙胺呈剂量依赖性地增加PRC、EC和PFC中DA和5-HT的含量，仅在PFC中发现了对右旋苯丙胺的主要DA反应，而在PRC和EC中没有发现。皮质醇增加DA和5-HT在PFC和PRC的同等程度，但在EC中引起主要的5-HT反应。当比较的药物之间的神经化学反应在一个平等的水平的行为激活，可卡因是更有力的thand-amphetamine在PFC中增加5-HT，而没有差异被发现在PRC或EC或在DA的反应在所有三个cortical areas. Conclusions我们得出结论，可卡因和d-安非他明增加DA和5-HT水平在PRC和EC在很大程度上相同的程度在PFC。
RationaleNeuroimaging studies with humans showed widespread activation of the cortex in response to psychostimulant drugs. However, the neurochemical nature of these brain activities is not characterized.ObjectiveThe aim of the present study was to investigate the effects of cocaine andd-amphetamine on dopamine (DA) and serotonin (5-HT) in cortical areas of the hippocampal network in comparison to the prefrontal cortex (PFC).Materials and methodsWe conducted in vivo microdialysis experiments in behaving rats measuring DA and 5-HT in the perirhinal cortex (PRC), entorhinal cortex (EC), and PFC, after application of cocaine (0, 5, 10, 20 mg/kg; i.p.) ord-amphetamine (0, 0.5, 1.0, 2.5 mg/kg; i.p.).ResultsCocaine andd-amphetamine dose-dependently increased DA and 5-HT levels in the PRC, EC, and PFC. A predominant DA response tod-amphetamine was only found in the PFC, but not in the PRC and EC. Cocaine increased DA and 5-HT to an equal extent in the PFC and PRC but induced a predominant 5-HT response in the EC. When comparing the neurochemical responses between the drugs at an equal level of behavioral activation, cocaine was more potent thand-amphetamine in increasing 5-HT in the PFC, while no differences were found in the PRC or EC or in the DA responses in all three cortical areas.ConclusionsWe conclude that cocaine andd-amphetamine increase DA and 5-HT levels in PRC and EC largely to the same extent as in the PFC.