Caseating Granulomas in Cutaneous Leishmaniasis
Caseating Granulomas in Cutaneous Leishmaniasis
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DOI：
10.1371/journal.pntd.0003255
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发表时间：
2014-10-01
影响因子：
3.8
通讯作者：
Khalifeh, Ibrahim
中科院分区：
文献类型：
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作者：
Aoun, Jessica;Habib, Robert;Khalifeh, Ibrahim
背景：干酪样肉芽肿通常与分枝杆菌感染（TB）相关，并且被认为在皮肤利什曼病（CL）中极其罕见。然而，尚无大型系列研究准确记录 CL 中干酪样肉芽肿的发生率。方法：由 317 名 CL 患者组成的多区域队列[叙利亚（157）、巴基斯坦（66）、黎巴嫩（47）、沙特阿拉伯（43）、埃塞俄比亚（2）和伊朗（2）]使用特殊染色（GMS、PAS、AFB 和 Gram）和聚合酶链反应（PCR）对 TB 和 CL 进行微生物评估。本研究中包括的所有病例均通过 PCR 确认为 CL，随后进行分子形态形成的限制性片段长度多态性分析，并且所有其他进行的研究均对其他生物体呈阴性。酌情使用卡方、t 检验或 Mann-Whitney 检验来比较肉芽肿类型的分类因素和连续因素。结果：在 195 例 (61.5%) CL 病例中发现肉芽肿，其中分为 49 例干酪样变 (25.2%)、9 例化脓性 (4.6%) 和 137 例无坏死结核样 (70.2%)。干酪样肉芽肿和结核样肉芽肿组在地理来源方面存在显着差异，沙特阿拉伯有更多病例存在干酪样肉芽肿（p
Background: Caseating granulomas are often associated with a mycobacterial infection (TB) and are thought to be exceedingly rare in cutaneous leishmaniasis (CL). However, no large series has accurately documented the incidence of caseating granulomas in CL.Methods: A multiregional cohort consisting of 317 patients with CL [Syria (157), Pakistan (66), Lebanon (47), Saudi Arabia (43), Ethiopia (2) and Iran (2)] was microorganisms was evaluated using special stains (GMS, PAS, AFB and Gram) and polymerase chain reaction (PCR) for TB and CL. All cases included in this study were confirmed as CL by PCR followed by restriction fragment length polymorphism analysis for molecular speciation and were negative for other organisms by all other studies performed. Categorical and continuous factors were compared for granuloma types using Chi-square, t-test or Mann-Whitney test as appropriate.Results: Granulomas were identified in 195 (61.5%) cases of CL and these were divided to 49 caseating (25.2%), 9 suppurative (4.6%) and 137 tuberculoid without necrosis (70.2%). Caseating and tuberculoid granuloma groups were significantly different in terms of the geographical source, with more cases harboring caseating granulomas in Saudi Arabia (p