STEADY-STATE TURNOVER AND BODY POOL OF ASCORBIC-ACID IN MAN
STEADY-STATE TURNOVER AND BODY POOL OF ASCORBIC-ACID IN MAN
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DOI：
10.1093/ajcn/32.3.530
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发表时间：
1979-01-01
影响因子：
7.1
通讯作者：
HORNIG, D
中科院分区：
文献类型：
--
作者：
KALLNER, A;HARTMANN, D;HORNIG, D
The time course of radioactivity in plasma and urine after oral administration of a single dose of (1-14C)ascorbic acid was followed in healthy nonsmoking male volunteers. The investigation was carried out under steady state conditions with regard to ascorbic acid intake (30-180 mg/day). Using pharmacokinetic principles, turnover, pool size, and rates of metabolism and excretion could be calculated. The half-life of ascorbic acid was inversely related to the dosage and the pool could be increased to about 20 mg/kg bodyweight by increasing the dosage. On a daily intake of about 100 mg ascorbic acid this pool size would probably be reached in 95% of the population.
