Metabolic syndrome and chronic kidney disease in Okinawa, Japan
Metabolic syndrome and chronic kidney disease in Okinawa, Japan
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DOI：
10.1038/sj.ki.5000050
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发表时间：
2006-01-01
影响因子：
19.6
通讯作者：
Iseki, K
中科院分区：
文献类型：
--
作者：
Tanaka, H;Shiohira, Y;Iseki, K
我们在日本冲绳的一个以医院为基础的筛查项目中评估了慢性肾脏病（CKD）的患病率。代谢综合征作为CKD的决定因素的意义采用多因素Logistic回归分析。共有6980名年龄在30-79岁的参与者参加了在富城中央医院进行的筛查项目。根据成人治疗组III（ATP III）的标准定义代谢综合征。还根据国家胆固醇教育计划（NCEP）的修改标准对数据进行了分析，该标准将腹部肥胖定义为男性腰围>= 85 cm，女性腰围>= 90 cm。CKD定义为试纸蛋白尿（>= 1 +）或肾小球滤过率（GFR）降低。使用简化的肾脏疾病饮食改良（MDRD）公式估计GFR。代谢综合征和CKD的患病率分别为12.8%和13.7%。代谢综合征是CKD的重要决定因素（校正比值比（OR）1.537，95%可信区间（CI）1.277-1.850，P < 0.0001）。与无代谢综合征危险因素的患者相比，有4种代谢综合征危险因素的患者的校正OR（95%CI）为1.770（1.215-2.579，P = 0.0029）。代谢综合征是年轻受试者的重要决定因素（≥ 60岁; OR 1.254，95% CI 0.906-1.735，NS）。采用改良标准，代谢综合征危险因素的数量与CKD患病率之间呈线性关系。研究结果表明，代谢综合征是日本冲绳60岁以下男性CKD的重要决定因素。
We assessed the prevalence of chronic kidney disease (CKD) in a hospital-based screening program in Okinawa, Japan. The significance of metabolic syndrome as a determinant of CKD was examined using multivariate logistic regression analysis. A total of 6980 participants, aged 30-79 years, participated in a screening program in Tomishiro Chuo Hospital. Metabolic syndrome was defined according to the criteria of the Adult Treatment Panel III (ATP III). Data were also analyzed according to the modified criteria of the National Cholesterol Education Program (NCEP) that defines abdominal obesity as a waist circumference of >= 85 cm in men and >= 90 cm in women. CKD was defined as dipstick proteinuria (>= 1 +) or a reduced glomerular filtration rate (GFR). GFR was estimated using the abbreviated Modification of Diet in Renal Disease (MDRD) formula. The prevalence of metabolic syndrome and CKD was 12.8 and 13.7%, respectively. Metabolic syndrome was a significant determinant of CKD (adjusted odds ratio (OR) 1.537 and 95% confidence interval (CI) 1.277-1.850, P < 0.0001). The adjusted OR (95% CI) was 1.770 (1.215-2.579, P = 0.0029) for those with four metabolic syndrome risk factors compared to those with no metabolic syndrome risk factors. Metabolic syndrome was a significant determinant for younger participants (= 60 years; OR 1.254, 95% CI 0.906-1.735, NS). The relationship between the number of metabolic syndrome risk factors and the prevalence of CKD was linear using the modified criteria. The results suggest that metabolic syndrome is a significant determinant of CKD in men under 60 years of age, in Okinawa, Japan.