Thyroid hormone action in neural development.
Thyroid hormone action in neural development.
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DOI：
10.1093/cercor/10.10.939
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发表时间：
2000-10
期刊：
影响因子：
3.7
通讯作者：
Catherine C. Thompson;Gregory B. Potter
中科院分区：
文献类型：
--
作者：
Catherine C. Thompson;Gregory B. Potter
甲状腺激素对大脑发育的影响已有超过世纪的文献记载。虽然甲状腺功能减退的大脑在许多方面表现正常，但功能障碍包括智力迟钝、共济失调和痉挛。由于发现了甲状腺激素的核受体作为转录因子发挥作用，最近的工作研究了甲状腺激素在大脑发育中的作用机制。受甲状腺激素调控的基因表达对于调节大脑发育很重要，这一预测刺激了对甲状腺激素反应基因的研究。在这里，我们回顾了一些已确定的基因，其表达模式与甲状腺功能减退脑中观察到的功能缺陷相关。最近确定的甲状腺激素反应基因包括突触结合蛋白相关基因1（Srg 1），突触结构和/或活动的假定介质，和无毛，转录辅因子，可能会影响其他甲状腺激素反应基因的表达。
Effects of thyroid hormone on development of the brain have been documented for over a century. Although in many respects the hypothyroid brain appears morphologically normal, functional impairments include mental retardation, ataxia and spasticity. Keyed by the discovery of nuclear receptors for thyroid hormone that function as transcription factors, recent work has examined the mechanism of thyroid hormone action in brain development. The prediction that gene expression regulated by thyroid hormone is important for mediating brain development has spurred the search for thyroid hormone-responsive genes. Here we review some of the identified genes whose expression patterns correlate with the functional deficits observed in the hypothyroid brain. Recently identified thyroid hormone-responsive genes include synaptotagmin-related gene 1 (Srg1), a putative mediator of synaptic structure and/or activity, and hairless, a transcriptional cofactor that may influence the expression of other thyroid hormone-responsive genes.