Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth
Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth
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DOI：
10.1016/j.jcf.2018.07.002
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发表时间：
2019-01-01
影响因子：
5.2
通讯作者：
Usemann, Jakob
中科院分区：
文献类型：
--
作者：
Korten, Insa;Kieninger, Elisabeth;Usemann, Jakob
背景：囊性纤维化（CF）的肺损害始于婴儿期。然而，监测早期肺部疾病的工具有限。呼吸频率（RR）作为一个关键的生命体征，在睡眠期间很容易评估，在急性呼吸道疾病期间会升高。因此，RR升高可能表明早期肺损伤，并可能作为一种诊断工具，在疾病monitoring.Methods：在一个前瞻性队列的婴儿CF诊断新生儿筛查和健康对照RR测量和呼吸系统症状，在整个婴儿期每周报告。婴儿进行了肺功能测量在第一周的生命。结果：分析包括5656测量153名婴儿（43 CF）。CF婴儿（健康对照组）的RR从6周龄时的43.2（40.5）/min降至50周龄时的28.3（24.6）/min。CF组婴儿的RR持续高于对照组（平均差异：4.15/min;（95%CI 2.86-5.44）; p
Background: Lung impairment in cystic fibrosis (CF) starts in infancy. However, tools to monitor early lung disease are limited. Respiratory rate (RR) as a key vital sign is easy to assess during sleep and is elevated during acute respiratory disease. Thus, elevated RR could indicate early lung impairment and potentially serve as a diagnostic tool in disease monitoring.Methods: In a prospective cohort of infants with CF diagnosed by newborn screening and healthy controls RR was measured and respiratory symptoms reported weekly throughout infancy. Infants performed a lung function measurement within the first weeks of life.Results: The analyses included 5656 measurements from 153 infants (43 with CF). RR declined from 43.2 (40.5)/min at 6 weeks of age to 28.3 (24.6)/min at 50 weeks in infants with CF (healthy controls). Infants with CF had consistently higher RR than controls (mean difference: 4.15/min; (95% CI 2.86-5.44); p