High altitude and oxidative stress
High altitude and oxidative stress
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DOI：
10.1016/j.resp.2007.03.013
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发表时间：
2007-09-30
影响因子：
2.3
通讯作者：
Radak, Zsolt
中科院分区：
文献类型：
--
作者：
Dosek, Agoston;Ohno, Hideko;Radak, Zsolt
暴露于高海拔地区，这是与降低氧气压力，可能会导致氧化/还原应激，增强生成的活性氧和氮（RONS），以及相关的氧化损伤脂质，蛋白质和DNA。氧化应激的严重程度与海拔高度有关。在暴露于高海拔期间，广泛的RONS生成系统被激活，包括线粒体电子传递链、黄嘌呤氧化酶和一氧化氮合酶。高海拔地区的酶和非酶抗氧化系统减弱，增加抗氧化维生素的营养摄入有利于减轻高原引起的氧化损伤。高海拔缺氧相关的氧化损伤模式类似于缺血/再灌注损伤。这种氧化挑战的适应过程需要相对较长的时间。在高海拔地区进行体育锻炼或增强体力活动会加剧氧化挑战的程度。因此，要特别注意抑制氧化应激的程度。(c)2007年由Elsevier B. V.出版。
Exposure to high altitude, which is associated with decreased oxygen pressure, could result in oxidative/reductive stress, enhanced generation of reactive oxygen and nitrogen species (RONS), and related oxidative damage to lipids, proteins, and DNA. The severity of oxidative challenge is related to the degree of altitude. A wide range of RONS generating systems are activated during exposure to high altitude, including the mitochondrial electron transport chain, xanthine oxidase, and nitric oxide synthase. High altitude appears to weaken the enzymatic and non-enzymatic antioxidant systems, and increased nutritional uptake of antioxidant vitamins are beneficial to reduce the altitude-induced oxidative damage. The pattern of high attitude exposure-associated oxidative damage resembles ischemia/reperfusion injury. The adaptive process to this oxidative challenge requires a relatively long period of time. Physical exercise or an enhanced level of physical activity at high altitude, exacerbates the extent of the oxidative challenge. Therefore, special attention is necessary to curb the degree of oxidative stress. (c) 2007 Published by Elsevier B.V.