From the Selectedworks of Marcel Adam Just Atypical Frontal-posterior Synchronization of Theory of Mind Regions in Autism during Mental State Attribution Atypical Frontal-posterior Synchronization of Theory of Mind Regions in Autism during Mental State Attribution
From the Selectedworks of Marcel Adam Just Atypical Frontal-posterior Synchronization of Theory of Mind Regions in Autism during Mental State Attribution Atypical Frontal-posterior Synchronization of Theory of Mind Regions in Autism during Mental State Attribution
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影响因子：
5.6
通讯作者：
R. Kana;T. Keller;N. Minshew;V. Cherkassky;M. Just
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作者：
R. Kana;T. Keller;N. Minshew;V. Cherkassky;M. Just
本研究使用功能磁共振成像（fMRI）研究自闭症患者在观看动画时心理理论（ToM）皮层网络的功能，在某些情况下，动画会将心理状态归因于动画几何图形。在皮层水平，心理化（金属状态的归因）是由心理理论网络的组成部分的协调和整合所支撑的，这些组成部分包括内侧额回、前扣带回和右颞顶交界处。关键的新发现是自闭症的功能连接不足（同步程度较低），特别是在精神状态归因过程中额叶和后部区域之间的连接。此外，与对照组相比，自闭症参与者的额叶ToM区域激活较少。在自闭症组中，一个独立的心理测量评估的心理理论能力和激活在右颞顶交界处可靠相关。这些结果为自闭症患者心理理论非典型加工的生物学基础提供了新的证据，暗示了额叶区域和更后部区域之间的连通性不足。
This study used fMRI to investigate the functioning of the Theory of Mind (ToM) cortical network in autism during the viewing of animations that in some conditions entailed the attribution of a mental state to animated geometric figures. At the cortical level, mentalizing (attribution of metal states) is underpinned by the coordination and integration of the components of the ToM network, which include the medial frontal gyrus, the anterior paracingulate, and the right temporoparietal junction. The pivotal new finding was a functional underconnectivity (a lower degree of synchronization) in autism, especially in the connections between frontal and posterior areas during the attribution of mental states. In addition, the frontal ToM regions activated less in participants with autism relative to control participants. In the autism group, an independent psychometric assessment of ToM ability and the activation in the right temporoparietal junction were reliably correlated. The results together provide new evidence for the biological basis of atypical processing of ToM in autism, implicating the underconnectivity between frontal regions and more posterior areas.