Testosterone Effects on the Brain in Transgender Men
Testosterone Effects on the Brain in Transgender Men
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DOI：
10.1093/cercor/bhx054
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发表时间：
2018-05-01
期刊：
影响因子：
3.7
通讯作者：
Savic-Berglund, Ivanka
中科院分区：
文献类型：
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作者：
Burke, Sarah M.;Manzouri, Amir H.;Savic-Berglund, Ivanka
跨性别者经历他们的性别认同和出生分配的性别之间的不一致。由此产生的性别焦虑症（GD），其中一些性别不一致的个人的经验，理论上是一个后果的非典型的大脑性别分化，但支持这种说法是不一致的。我们最近发现，GD与涉及自我参照思维和自身身体感知的断开网络有关。在这里，我们调查了跨性别男性（出生时被分配为女性，具有男性性别认同）的这些网络如何受到睾丸激素的影响。在22名跨性别男性中，我们在睾酮治疗前后获得了T-1加权，弥散加权和静息状态功能磁共振成像扫描，测量皮质厚度（Cth），皮质下体积，各向异性分数（FA）和功能连接。十九顺性别控制（男性和女性）也扫描了两次。内侧前额叶皮质（mPFC）在跨性别男性比对照组治疗前厚，治疗后保持不变。与对照组相比，替吉奥治疗导致岛叶皮质Cth增加，mPFC和枕叶皮质之间皮质-皮质厚度协变变化，连接这些区域的额枕束FA增加，mPFC和颞顶交界处之间的功能连接增加。总之，在跨性别男性睾酮治疗导致功能和结构的变化，在自我参照和自己的身体感知领域。
Transgender individuals experience incongruence between their gender identity and birth-assigned sex. The resulting gender dysphoria (GD), which some gender-incongruent individuals experience, is theorized to be a consequence of atypical cerebral sexual differentiation, but support for this assertion is inconsistent. We recently found that GD is associated with disconnected networks involved in self-referential thinking and own body perception. Here, we investigate how these networks in trans men (assigned female at birth with male gender identity) are affected by testosterone. In 22 trans men, we obtained T-1-weighted, diffusion-weighted, and resting-state functional magnetic resonance imaging scans before and after testosterone treatment, measuring cortical thickness (Cth), subcortical volumes, fractional anisotropy (FA), and functional connectivity. Nineteen cisgender controls (male and female) were also scanned twice. The medial prefrontal cortex (mPFC) was thicker in trans men than controls pretreatment, and remained unchanged posttreatment. Testosterone treatment resulted in increased Cth in the insular cortex, changes in cortico-cortical thickness covariation between mPFC and occipital cortex, increased FA in the fronto-occipital tract connecting these regions, and increased functional connectivity between mPFC and temporo-parietal junction, compared with controls. Concluding, in trans men testosterone treatment resulted in functional and structural changes in self-referential and own body perception areas.