The Walking Impairment Questionnaire stair-climbing score predicts mortality in men and women with peripheral arterial disease
The Walking Impairment Questionnaire stair-climbing score predicts mortality in men and women with peripheral arterial disease
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DOI：
10.1016/j.jvs.2011.12.010
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发表时间：
2012-06-01
影响因子：
4.3
通讯作者：
McDermott, Mary M.
中科院分区：
文献类型：
--
作者：
Jain, Atul;Liu, Kiang;McDermott, Mary M.
目的：步行障碍问卷（WIQ）测量了患有下肢外周动脉疾病（PAD）的男性和女性自我报告的步行距离、步行速度和爬楼梯能力。我们确定是否较差的WIQ评分与较高的全因和心血管疾病（CVD）死亡率在个人与无PAD。方法：我们确定了1048名男性和女性与无PAD从芝加哥地区的医疗中心。参与者在基线时完成了WIQ，并接受了中位数为4.5年的监测。考克斯比例风险模型被用来与基线WIQ分数与死亡，调整年龄，性别，种族，踝肱指数（ABI），合并症，和其他covariates.Results：在随访期间，461名参与者（44.0%）死亡，包括158例死于心血管疾病。WIQ爬楼梯得分最低基线四分位数的PAD参与者的全因死亡率较高（风险比，1.70; 95%置信区间，1.08-2.66，P = .02）和较高的CVD死亡率（风险比，3.11; 95%置信区间，1.30-7.47，P = 0.01）与基线WIQ爬楼梯评分最高的患者相比。在PAD参与者中，较低的基线WIQ距离或速度评分与全因死亡率（趋势分别为P = 0.20和P = 0.07）或CVD死亡率（趋势分别为P = 0.51和P = 0.33）无显著相关性。在非PAD参与者中，较低的基线WIQ爬楼梯、距离或速度评分与全因死亡率无显著相关性（趋势分别为P = 0.94、P = 0.69和P = 0.26）或CVD死亡率（趋势分别为P = .28、P = .68和P = .78）。在PAD参与者中，较低的WIQ爬楼梯评分与较高的全因死亡率和CVD死亡率相关，独立于ABI和其他协变量。（J Vasc Surg 2012;55：1662-73.）
Objective: The Walking Impairment Questionnaire (WIQ) measures self-reported walking distance, walking speed, and stair-climbing ability in men and women with lower extremity peripheral arterial disease (PAD). We determined whether poorer WIQ scores are associated with higher all-cause and cardiovascular disease (CVD) mortality in individuals with and without PAD.Methods: We identified 1048 men and women with and without PAD from Chicago-area medical centers. Participants completed the WIQ at baseline and were monitored for a median of 4.5 years. Cox proportional hazards models were used to relate baseline WIQ scores with death, adjusting for age, sex, race, the ankle-brachial index (ABI), comorbidities, and other covariates.Results: During follow-up, 461 participants (44.0%) died, including 158 deaths from CVD. PAD participants in the lowest baseline quartile of the WIQ stair-climbing scores had higher all-cause mortality (hazard ratio, 1.70; 95% confidence interval, 1.08-2.66, P = .02) and higher CVD mortality (hazard ratio, 3.11; 95% confidence interval, 1.30-7.47, P = .01) compared with those with the highest baseline WIQ stair-climbing score. Among PAD participants, there were no significant associations of lower baseline WIQ distance or speed scores with rates of all-cause mortality (P = .20 and P = .07 for trend, respectively) or CVD mortality (P = .51 and P = .33 for trend, respectively). Among non-PAD participants there were no significant associations of lower baseline WIQ stair-climbing, distance, or speed score with rates of all-cause mortality (P = .94, P = .69, and P = .26, for trend, respectively) or CVD mortality (P = .28, P = .68, and P = .78, for trend, respectively).Conclusions: Among participants with PAD, lower WIQ stair-climbing scores are associated with higher all-cause and CVD mortality, independently of the ABI and other covariates. (J Vasc Surg 2012;55:1662-73.)