Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance -: The Inter99 study
Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance -: The Inter99 study
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DOI：
10.2337/diacare.28.6.1397
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发表时间：
2005-06-01
期刊：
影响因子：
16.2
通讯作者：
Borch-Johnsen, K
中科院分区：
文献类型：
--
作者：
Lau, C;Pedersen, O;Borch-Johnsen, K
目的-研究每日血糖指数每日血糖，负荷，单糖，膳食纤维，和30- 60岁的非糖尿病丹麦男性和女性的胰岛素抵抗措施的患病率之间的关系。研究设计和方法-inter 99研究是一项非药物干预研究。我们使用基线数据并检查了5，675名30 - 60岁受试者中碳水化合物相关饮食因素与胰岛素抵抗估计值之间的横断面相关性。通过自填食物频率问卷估计饮食摄入量，并使用胰岛素抵抗稳态模型评估（HOMA-IR）估计胰岛素抵抗。以HOMA-IR为因变量，以碳水化合物相关因素为解释变量进行多元回归分析。所有模型均校正了年龄、性别、吸烟、体力活动、总能量摄入、BMI和腰围。结果乳糖摄入量与HOMA-IR呈正相关（P < 0.0001），而每日血糖负荷和葡萄糖、果糖、膳食纤维、总碳水化合物、水果和蔬菜摄入量与HOMA-IR呈负相关（P < 0.05）。膳食纤维的摄入解释了与每日血糖负荷和总碳水化合物的关联，并减弱了与水果和蔬菜的关联。每日血糖指数或sucrose.CONCLUSIONS -习惯性摄入高血糖指数和高血糖负荷的饮食或高含量的总碳水化合物（包括单糖）的饮食与胰岛素抵抗的可能性无关。此外，膳食纤维的摄入量与胰岛素抵抗的可能性呈负相关。
OBJECTIVE - To examine the relationship between daily glycemic index daily glycemic, load, simple sugars, dietary fiber, and the prevalence of a measure of insulin resistance in 30- to 60-year-old nondiabetic Danish men and women.RESEARCH DESIGN AND METHODS - The inter99 study is a nonpharmacological intervention study. We used baseline data and examined cross-sectional associations between carbohydrate-related dietary factors and an estimate of insulin resistance in 5,675 subjects at 30 - 60 years. The dietary intake was estimated from a self-administered food frequency questionnaire, and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Multiple regressions were performed with HOMA-IR as the dependent variable and carbohydrate-related factors as explanatory variables. All models were adjusted for age, sex, smoking, physical activity, total energy intake, BMI, and waist circumference.RESULTS - intake of lactose was positively associated with HOMA-IR (P < 0.0001), whereas daily glycemic load and intake of glucose, fructose, dietary fiber, total carbohydrate, fruit, and vegetables were inversely associated with HOMA-IR (P < 0.05). Intake of dietary fiber explained the associations with daily glycemic load and total carbohydrate and attenuated the association with fruit and vegetables. No significant associations were observed for daily glycemic index or sucrose.CONCLUSIONS - Habitual intake of diets with a high glycemic index and high glycemic load or diets with a high content of total carbohydrate including simple sugars was not associated with the probability of having insulin resistance. Furthermore, intake of dietary fiber was inversely associated with the probability of having insulin resistance.