MEN WITH INTENSIVE OCCUPATIONAL EXPOSURE TO DDT - A CLINICAL AND CHEMICAL STUDY
MEN WITH INTENSIVE OCCUPATIONAL EXPOSURE TO DDT - A CLINICAL AND CHEMICAL STUDY
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DOI：
10.1080/00039896.1967.10664995
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发表时间：
1967-01-01
期刊：
影响因子：
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通讯作者：
BIROS, FJ
中科院分区：
文献类型：
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作者：
LAWS, ER;CURLEY, A;BIROS, FJ
对35名男子进行了一项研究，他们在一家自1947年以来一直专门生产滴滴涕的工厂工作了11至19年，现在平均生产600万磅滴滴涕。月病史、体格检查、常规临床实验室检查和胸部X光片的结果均未显示接触滴滴涕造成的任何不良影响。男性脂肪中滴滴涕异构体和代谢物总量的总体储存范围为38至647 ppm，而一般人群的平均储存量为8 ppm。根据脂肪中DDT的储存量和尿中DDA的排泄量，估计20名职业接触量高的男子平均每日摄入DDT为每人每天17.5至18毫克，而一般人群平均每人每天摄入0.04毫克。工人脂肪中DDT相关物质总量与血清中DDT相关物质总量呈显著正相关（r =+0.64）。脂肪中的浓度平均为血清中的338倍。工人以DDE的形式储存较少比例的DDT相关材料，这种差异主要与强度而不是暴露时间有关。DDE [二氯二苯二氯乙烯]作为排泄物的重要性相对较低，而DDA [双（氯苯基）乙酸]作为排泄物的重要性在职业暴露的男性中比在一般人群中要高得多。
A study was made of 35 men with 11 to 19 years of exposure in a plant that has produced DDT continuously and exclusively since 1947 and now produces an average of 6 million lb./month. Findings from medical history, physical examination, routine clinical laboratory tests, and chest X-ray film did not reveal any ill effects attributable to exposure to DDT. The overall range of storage of the sum of isomers and metabolites of DDT in the men''s fat was 38 to 647 ppm as compared to an average of 8 ppm for the general population. Based on their storage of DDT in fat and excretion of DDA in urine it was estimated that the average daily intake of DDT by the 20 men with high occupational exposure was 17.5 to 18 mg per man per day as compared to an average of 0.04 mg per man per day for the general population. There was significant correlation (r = + 0.64) between the concentration of total DDT-related material in the fat and serum of the workers. The concentration in fat averaged 338 times greater than that in serum. Workers store a smaller proportion of DDT-related material in the form of DDE, and the difference is related chiefly to intensity rather than duration of exposure. DDE [Dichlorodiphenyl dichloroethylene] is relatively much less important and DDA [Bis(chlorophenyl) acetic acid] much more important as excretory products in occupationally exposed men than in men of the general population.