Anti-Mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition
Anti-Mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition
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抗穆勒氏管激素和抑制素 B 在卵巢衰老和更年期过渡定义中的作用
DOI：
10.1210/jc.2008-0567
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发表时间：
2008-09-01
影响因子：
5.8
通讯作者：
Randolph, John F., Jr.
中科院分区：
文献类型：
--
作者：
Sowers, MaryFran R.;Eyvazzadeh, Aimee D.;Randolph, John F., Jr.
背景/目标：该研究的目的是确定抗苗勒管激素（AMH）和抗苗勒管激素B是否是可行的内分泌生物标志物，用于确定从开始到末次月经期（FMP）的绝经过渡。我们检测了抗苗勒氏管激素，抗苗勒氏菌素B，从1993年开始，当所有妇女都在卵泡发育前，和围绝经期绝经阶段。随后，每位女性都有一份记录在案的FMP。分析结果被拟合为个人妇女的配置文件，然后与时间FMP和年龄在FMP作为outcomes.Results：从6个时间点的FMP，（日志）AMH纵向配置文件之前的年度值的基础上下降，并高度相关的时间点5年前FMP [包括观察到的和低于检测值（P < 0.0001和P = 0.0001，分别）]。基线AMH谱也与FMP时的年龄相关（P = 0.035）。下降（log）的BMPbin B曲线模型（包括观察值和低于检测值）与FMP的时间相关（分别为P < 0.0001和P = 0.0003）。有没有显着的相关性（log）AMBIN B配置文件与年龄在FMP.Conclusions：AMH，内分泌标志物，反映了休息的原始卵泡生长卵泡的过渡，下降到一个时间点5年前的FMP，这可能代表了一个重要的生物学转折点，在menopausetransition。在FMP前4-5年也观察到低水平和不可检测水平的β-D-半胱氨酸B水平，但对FMP时间或FMP时的年龄预测性较低。
Context/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP).Design: We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre-and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes.Results: Based on annual values from six time points prior to the FMP, (log)AMH longitudinal profiles declined and were highly associated with a time point 5 yr prior to FMP [including both observed and values below detection (P < 0.0001 and P = 0.0001, respectively)]. Baseline AMH profiles were also associated with age at FMP(P = 0.035). Models of declining (log) inhibin B profiles (including both observed and values below detection) were associated with time to FMP(P < 0.0001 and P = 0.0003, respectively). There was no significant association of (log)inhibin B profiles with age at FMP.Conclusions: AMH, an endocrine marker that reflects the transition of resting primordial follicles to growing follicles, declined to a time point 5 yr prior to the FMP; this may represent a critical biological juncture in the menopausetransition. Low and nondetectable levels inhibin B levels also were observed 4-5 yr prior to the FMP but were less predictive of time to FMP or age at FMP.