Omega-3 fatty acids and risk of cognitive impairment and dementia
Omega-3 fatty acids and risk of cognitive impairment and dementia
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DOI：
10.3233/jad-2003-5407
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发表时间：
2003-01-01
影响因子：
4
通讯作者：
Holub, Bruce J.
中科院分区：
文献类型：
--
作者：
Laurin, Danielle;Verreault, Rene;Holub, Bruce J.
有人建议，膳食中 omega-3 多不饱和脂肪酸的摄入量可能与痴呆和认知能力下降的风险呈负相关。该分析检查了 omega-3 多不饱和脂肪酸的血浆浓度与认知障碍和痴呆的患病率和发生率之间的关联。报告的数据针对 65 岁或以上的受试者，他们在加拿大健康与老龄化研究的前两波（1991-1992 年和 1996-1997 年）中进行了完整的临床评估。主要结果指标是基线时磷脂部分中脂肪酸的平均相对血浆浓度的认知障碍和痴呆。结果根据年龄、性别、教育程度、吸烟、饮酒、体重指数、心血管疾病史和载脂蛋白 E e4 基因型进行了调整。在横断面分析中，对照组与认知障碍和痴呆症的常见病例之间没有观察到 omega-3 多不饱和脂肪酸浓度存在显着差异。在前瞻性分析中，与对照组相比，认知障碍病例的二十碳五烯酸（p < 0.01）浓度较高，而痴呆病例的二十二碳六烯酸（p < 0.07）、omega-3（p < 0.04）和总多不饱和脂肪酸（p < 0.03）浓度较高。这些发现并不支持 omega-3 多不饱和脂肪酸在认知功能和痴呆症中发挥保护作用的假设。
It has been suggested that the dietary intake of omega-3 polyunsaturated fatty acids could be inversely related to the risk of dementia and cognitive decline. This analysis examined the association between plasma concentration of omega-3 polyunsaturated fatty acids and prevalence and incidence of cognitive impairment and dementia. Data are reported on subjects 65 years or older who had a complete clinical evaluation at the first two waves (1991-1992 and 1996-1997) of the Canadian Study of Health and Aging. Main outcome measures were cognitive impairment and dementia by mean relative plasma concentrations of fatty acids in the phospholipid fraction at baseline. Results were adjusted for age, sex, education, smoking, alcohol intake, body mass index, history of cardiovascular disease, and apolipoprotein E e4 genotype. In the cross-sectional analysis, no significant difference in omega-3 polyunsaturated fatty acid concentrations was observed between controls and both prevalent cases of cognitive impairment and dementia. In the prospective analysis, a higher eicosapentaenoic acid (p < 0.01) concentration was found in cognitively impaired cases compared to controls while higher docosahexaenoic acid (p < 0.07), omega-3 (p < 0.04) and total polyunsaturated fatty acid (p < 0.03) concentrations were found in dementia cases. These findings do not support the hypothesis that omega-3 polyunsaturated fatty acids play a protective role in cognitive function and dementia.