The integrity of the blood-brain barrier in Alzheimer's disease
The integrity of the blood-brain barrier in Alzheimer's disease
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DOI：
10.1111/j.1600-0404.2007.00823.x
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发表时间：
2007-06-01
影响因子：
3.5
通讯作者：
Winblad, B.
中科院分区：
文献类型：
--
作者：
Algotsson, A.;Winblad, B.
目的探讨阿尔茨海默病（AD）患者血脑屏障（BBB）的完整性。材料和方法-157例患者（45%男性）的平均年龄为69.7（9.4）岁（范围51-88岁）。患者接受了彻底的检查，包括磁共振成像或计算机断层扫描的大脑。使用脑脊液（CSF）/血浆白蛋白比率（白蛋白比率）作为BBB功能的量度。结果：白蛋白比率和血浆肌酐存在性别差异，男性的值更高（P < 0.001）。应用实验室参考限值（< 9.2）时，42%的男性和13%的女性（P < 0.001）有轻度至中度BBB功能障碍。当控制假定的混杂因素时，男性（P = 0.002）和血浆肌酐（P = 0.009）均与白蛋白比值独立相关。结论：部分AD患者的BBB功能障碍，女性和男性都是如此。这种功能障碍可能会影响有害物质和有益物质穿过屏障的清除。肾功能可能对BBB有影响。
Objective - To evaluate the integrity of the blood-brain barrier (BBB) in incident Alzheimer's disease (AD). Materials and methods - The mean age of the 157 patients (45% men) was 69.7(9.4) years (range 51-88 years). The patients had undergone a thorough investigation including magnetic resonance imaging or computed tomography of the brain. The cerebrospinal(CSF)/plasma albumin ratio (albumin ratio) was used as a measure of BBB function. Results - There were gender differences with respect to albumin ratio and plasma creatinine with higher values in men (P < 0.001). 42% of the men and 13% of the women (P < 0.001) had a mild to moderate BBB dysfunction when applying the reference limit of the laboratory ( < 9.2). Both male gender (P = 0.002) and plasma creatinine (P = 0.009) were independently associated with the albumin ratio when controlling for putative confounders. Conclusions - The BBB is dysfunctional in a portion of patients with AD, both women and, primarily, men. The dysfunction might influence the clearance of both harmful and beneficial substances across the barrier. Renal function might have an impact on the BBB.