Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits
Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits
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DOI：
10.1038/88384
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发表时间：
2001-06-01
影响因子：
25
通讯作者：
Cho, KW
中科院分区：
文献类型：
--
作者：
Cho, KW
时区旅行者遇到一种光明和黑暗的模式，他们的内源性昼夜节律适应新的外部时间线索，直到两个计时系统同步1，但两个计时系统之间的同步长期重复干扰损害生理和心理健康，并诱发压力2。反复暴露于时差反应后机组人员的唾液皮质醇水平显著高于短途飞行后3，且较高的皮质醇水平与依赖于非语义刺激的认知缺陷相关3。本研究表明，显着延长皮质醇升高产生颞叶体积减少和空间学习和记忆的赤字，这些认知缺陷变得明显后五年暴露于高皮质醇水平。
Time-zone travelers encounter a pattern of light and darkness, and their endogenous circadian rhythms adapt to the new external time cue until both timing systems synchronize 1, but the long-term repeated disturbance of synchronization between the two timing systems impairs physiological and psychological health and induces stress 2. Salivary cortisol levels in cabin crew after repeated exposure to jet lag were significantly higher than after short distance flights 3, and the higher cortisol levels were associated with cognitive deficits that were dependent on non-semantic stimuli 3. The present study demonstrates that significant prolonged cortisol elevations produce reduced temporal lobe volume and deficits in spatial learning and memory; these cognitive deficits became apparent after five years of exposure to high cortisol levels.