Emerging roles of resolvins in the resolution of inflammation and pain.
Emerging roles of resolvins in the resolution of inflammation and pain.
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DOI：
10.1016/j.tins.2011.08.005
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发表时间：
2011-11
影响因子：
15.9
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Ji RR;Xu ZZ;Strichartz G;Serhan CN
溶血素，包括D和E系列溶血素，是由omega-3多不饱和脂肪酸、二十二碳六烯酸(DHA)和二十碳五烯酸(EPA)在急性炎症缓解阶段产生的内源性脂质介质。已知的是，在几种炎症动物模型中，溶血素具有强大的抗炎和促消解作用。最近的研究结果还表明，解决素E1和解决素D1各自都能有效地抑制炎症和术后疼痛。本文综述了溶血素通过调节炎症介质、瞬时受体电位离子通道和脊髓突触传递，作用于免疫细胞和神经元中的受体，从而使夸张的疼痛正常化的机制。可溶蛋白可能为预防和治疗与炎症相关的疼痛状况提供新的治疗方法。
Resolvins, including D and E series resolvins, are endogenous lipid mediators generated during the resolution phase of acute inflammation from the omega-3 polyunsaturated fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Resolvins are known to have potent anti-inflammatory and pro-resolution actions in several animal models of inflammation. Recent findings also demonstrate that resolvin E1 and resolvin D1 can each potently dampen inflammatory and postoperative pain. This review focuses on the mechanisms by which resolvins act on their receptors in immune cells and neurons to normalize exaggerated pain, via regulating inflammatory mediators, transient receptor potential (TRP) ion channels, and spinal cord synaptic transmission. Resolvins may offer novel therapeutic approaches for preventing and treating pain conditions associated with inflammation.