Lymphocytes are important in early atherosclerosis
Lymphocytes are important in early atherosclerosis
复制标题
DOI：
10.1172/jci200111380
复制
发表时间：
2001-07-01
影响因子：
15.9
通讯作者：
Schindler, C
中科院分区：
文献类型：
--
作者：
Song, L;Leung, C;Schindler, C
淋巴细胞代表一种潜在的重要促炎细胞，定位于动脉粥样硬化病变。为了确定它们是否会导致病变发展，将易患动脉粥样硬化的 (LDLR-/-) 小鼠与淋巴细胞缺陷型 (RAG1(-/-)) 小鼠杂交，产生双敲除后代。采用西式饮食 (WTD) 8 周后，与匹配的 LDLR-/- 对照相比，双基因敲除小鼠的病变发展减少了 54%。然而，随着WTD持续12周和16周，病变面积的这些显着差异逐渐消退。与这一观察结果一致，组织学研究确定 RAG1/LDL-R 双敲除小鼠中病变的发生和早期进展被延迟。病变面积的差异与血浆脂质水平的任何显着变化无关。这些研究表明淋巴细胞在动脉粥样硬化形成的早期发挥重要作用。
Lymphocytes represent a potentially important proinflammatory cell that localizes to atherosclerotic lesions. To determine whether they contribute to lesion development, atherosclerosis-prone (LDLR-/-) mice were crossed with lymphocyte-deficient (RAG1(-/-)) mice to generate double knockout progeny. After 8 weeks on a Western-type diet (WTD), lesion development was reduced by 54% in double knockout mice, as compared with matched LDLR-/- controls. However, these significant differences in lesion area gradually subsided as the WTD was continued for 12 and 16 weeks. Consistent with this observation, histological studies determined that lesion initiation and early progression were delayed in RAG1/LDL-R double knockout mice. Differences in lesion area did not correlate with any significant alterations in plasma lipid levels. These studies suggest that lymphocytes play an important role early in atherogenesis.