Ion channel remodeling in gastrointestinal inflammation.
Ion channel remodeling in gastrointestinal inflammation.
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DOI：
10.1111/j.1365-2982.2010.01560.x
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发表时间：
2010-10
影响因子：
3.5
通讯作者：
Kang M
中科院分区：
文献类型：
--
作者：
Akbarali HI;G Hawkins E;Ross GR;Kang M
胃肠道炎症显着影响平滑肌细胞的电兴奋性。过去几年，在建立胃肠道炎症中离子通道功能改变的机制方面已经取得了相当大的进展。炎症后平滑肌中离子通道功能调节的分子基础细节已经开始出现。其中包括 L 型 Ca2+ 通道和 ATP 敏感 K+ 通道的平滑肌亚型的蛋白质和基因表达的变化。最近的注意力还集中在翻译后修饰上，作为在蛋白质/基因表达不发生变化的情况下改变离子通道功能的主要手段。丝氨酸/苏氨酸或酪氨酸残基的蛋白质磷酸化、半胱氨酸硫醇修饰和酪氨酸硝化是受氧化/亚硝化应激影响的潜在机制，这些应激改变了离子通道的门控动力学。总的来说，这些发现表明，除了结构重塑之外，炎症还会导致平滑肌细胞的电重塑。本综述的目的是综合我们目前对导致胃肠道炎症期间离子通道功能改变的分子机制的理解，并解决可能导致靶向新疗法的潜在领域
Gastrointestinal inflammation significantly affects the electrical excitability of smooth muscle cells. Considerable progress over the last few years have been made to establish the mechanisms by which ion channel function is altered in the setting of gastrointestinal inflammation. Details have begun to emerge on the molecular basis by which ion channel function may be regulated in smooth muscle following inflammation. These include changes in protein and gene expression of the smooth muscle isoform of L-type Ca2+ channels and ATP-sensitive K+ channels. Recent attention has also focused on post-translational modifications as a primary means of altering ion channel function in the absence of changes in protein/gene expression. Protein phosphorylation of serine/theronine or tyrosine residues, cysteine thiol modifications, and tyrosine nitration are potential mechanisms affected by oxidative/nitrosative stress that alter the gating kinetics of ion channels. Collectively, these findings suggest that inflammation results in electrical remodeling of smooth muscle cells in addition to structural remodeling. The purpose of this review is to synthesize our current understanding regarding molecular mechanisms that result in altered ion channel function during gastrointestinal inflammation and to address potential areas that can lead to targeted new therapies
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影响因子：
56.9
作者：
Doyle, DA;Cabral, JM;MacKinnon, R
通讯作者：
MacKinnon, R
DOI：
10.1073/pnas.0902675106
发表时间：
2009-11-24
影响因子：
11.1
作者：
Chuang, Huai-hu;Lin, Stephanie
通讯作者：
Lin, Stephanie
影响因子：
--
作者：
Galamb O;Györffy B;Sipos F;Spisák S;Németh AM;Miheller P;Tulassay Z;Dinya E;Molnár B
通讯作者：
Molnár B
影响因子：
33.6
作者：
Dai S;Hall DD;Hell JW
通讯作者：
Hell JW
影响因子：
4.9
作者：
Guzman, Jorge;Yu, Jun Ge;Christofi, Fievos L.
通讯作者：
Christofi, Fievos L.