The virome of the last eukaryotic common ancestor and eukaryogenesis
The virome of the last eukaryotic common ancestor and eukaryogenesis
复制标题
DOI：
10.1038/s41564-023-01378-y
复制
发表时间：
2023-05-01
影响因子：
28.3
通讯作者：
Koonin，Eugene V.
中科院分区：
文献类型：
--
作者：
Krupovic，Mart;Dolja，Valerian V.;Koonin，Eugene V.
所有现存的真核生物都起源于最后一个真核生物共同祖先（LECA），该共同祖先被认为具有复杂的细胞组织。为了深入了解LECA生物学和真核发生-真核细胞的起源，这仍然知之甚少-我们重建了LECA病毒库。我们编制了所有主要病毒类群的真核宿主清单，并通过推断这些病毒组的起源来重建LECA病毒组。LECA病毒组的起源可以追溯到一小部分细菌病毒，而不是古细菌病毒。这种来源的LECA病毒可能是由于细菌起源的真核细胞膜，这是最兼容的两个内共生事件的真核细胞发生的互养模型。在第一次内共生中，细菌宿主吞噬了Asgard古菌，由于外膜上缺乏古菌病毒受体，阻止了古菌病毒进入。
All extant eukaryotes descend from the last eukaryotic common ancestor (LECA), which is thought to have featured complex cellular organization. To gain insight into LECA biology and eukaryogenesis—the origin of the eukaryotic cell, which remains poorly understood—we reconstructed the LECA virus repertoire. We compiled an inventory of eukaryotic hosts of all major virus taxa and reconstructed the LECA virome by inferring the origins of these groups of viruses. The origin of the LECA virome can be traced back to a small set of bacterial—not archaeal—viruses. This provenance of the LECA virome is probably due to the bacterial origin of eukaryotic membranes, which is most compatible with two endosymbiosis events in a syntrophic model of eukaryogenesis. In the first endosymbiosis, a bacterial host engulfed an Asgard archaeon, preventing archaeal viruses from entry owing to a lack of archaeal virus receptors on the external membranes.