THE INTRACELLULAR DEGRADATION OF POLY(EPSILON-CAPROLACTONE)
THE INTRACELLULAR DEGRADATION OF POLY(EPSILON-CAPROLACTONE)
复制标题
DOI：
10.1002/jbm.820190408
复制
发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
PITT, CG
中科院分区：
文献类型：
--
作者：
WOODWARD, SC;BREWER, PS;PITT, CG
保利(.epsilon。（-己内酯）[PEC]是一种可生物降解的脂肪族聚酯，它的降解过程分为两个阶段：第一个漫长的阶段涉及酯基的非酶水解裂解，第二阶段开始于聚合物结晶性更强和分子量更低的时候。通过植入含有25 mg低分子量（3000）PEC粉末，106-500 .mu的明胶胶囊来检测第二期的细胞事件。M，老鼠。PEC片段最终在巨噬细胞和巨细胞的吞噬体中被降解，这一过程在某些部位需要< 13天才能完成。在成纤维细胞中也发现了PEC。这些研究支持细胞内降解PEC作为降解的主要途径，一旦老化的聚合物的MW降低到3000或更少。
Poly(.epsilon.-caprolactone) [PEC], a biodegradable aliphatic polyester, undergoes a 2-stage degradation process: The 1st lengthy phase involves nonenzymatic hydrolytic cleavage of ester groups, the 2nd phase beginning when the polymer is more highly crystalline, and of low MW. The cellular events of the 2nd phase were examined by implanting gelatin capsules containing 25 mg of low MW (3000) PEC powders, 106-500 .mu.m, in rats. PEC fragments ultimately were degraded in phagosomes of macrophages and giant cells, the process requiring < 13 days for completion at some sites. PEC was also identified within fibroblasts. These studies support the intracellular degradation of PEC as the principal pathway of degradation once the MW of the aged polymer is reduced to 3000 or less.