Circulating TNF Receptors 1 and 2 Predict ESRD in Type 2 Diabetes
Circulating TNF Receptors 1 and 2 Predict ESRD in Type 2 Diabetes
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DOI：
10.1681/asn.2011060627
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发表时间：
2012-03-01
影响因子：
13.6
通讯作者：
Krolewski, Andrzej S.
中科院分区：
文献类型：
--
作者：
Niewczas, Monika A.;Gohda, Tomohito;Krolewski, Andrzej S.
促炎细胞因子的水平与患 2 型糖尿病的风险相关，但慢性炎症是否会导致糖尿病并发症（如终末期肾病）的发生尚不清楚。 20世纪90年代，我们招募了410名2型糖尿病患者进行糖尿病肾病研究，并在入组时记录他们的特征。在 12 年的随访期间，59 名患者出现 ESRD（每 1000 名患者年 17 名），84 名患者未患 ESRD 死亡（每 1000 名患者年 24 名）。在研究样本中测量了全身炎症、内皮功能障碍和 TNF 通路的血浆标志物。在检查的标记物中，只有 TNF 受体 1 和 2（TNFR1 和 TNFR2）与 ESRD 风险相关。这两个标志物高度相关，但 ESRD 与 TNFR1 的相关性更强。 12 年后，TNFR1 最高四分位数的患者 ESRD 累积发生率为 54%，而其他四分位数仅为 3%（P
Levels of proinflammatory cytokines associate with risk for developing type 2 diabetes but whether chronic inflammation contributes to the development of diabetic complications, such as ESRD, is unknown. In the 1990s, we recruited 410 patients with type 2 diabetes for studies of diabetic nephropathy and recorded their characteristics at enrollment. During 12 years of follow-up, 59 patients developed ESRD (17 per 1000 patient-years) and 84 patients died without ESRD (24 per 1000 patient-years). Plasma markers of systemic inflammation, endothelial dysfunction, and the TNF pathway were measured in the study entry samples. Of the examined markers, only TNF receptors 1 and 2 (TNFR1 and TNFR2) associated with risk for ESRD. These two markers were highly correlated, but ESRD associated more strongly with TNFR1. The cumulative incidence of ESRD for patients in the highest TNFR1 quartile was 54% after 12 years but only 3% for the other quartiles (P