Renal Transport of Organic Anions and Cations
Renal Transport of Organic Anions and Cations
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DOI：
10.1002/cphy.c100084
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发表时间：
2011-10-01
影响因子：
5.8
通讯作者：
Wright, Stephen H.
中科院分区：
文献类型：
--
作者：
Pelis, Ryan M.;Wright, Stephen H.
有机阴离子和阳离子(分别为OAS和OCS)组成了一系列具有生理、药理和毒理重要性的非常多样化的化合物。肾脏，主要是肾近端小管，在调节这些有机电解质的血浆浓度和清除体内潜在有毒的外源物质方面发挥着关键作用，这一过程涉及到活跃的跨上皮分泌。这种跨上皮运输包括在肾小管细胞的基底、外侧和管腔方面分开的进入和退出步骤。基底侧和管腔内的OA和OC运输反映了在近端小管细胞的每一极平行排列的一套独立蛋白的协同活动。克隆几个不同转运家族的多个成员，随后表征它们的活性，以及它们在肾脏不同区域的亚细胞定位，现在可以开发描述OAS和OCS肾脏分泌的分子基础的模型。关于其中许多过程的自然发生的遗传变异的新信息，为观察到的药物疗效的可变性和人类群体中不需要的药物-药物相互作用的基础提供了洞察力。本审查审查了最近关于这些问题的工作。(C)2011年美国生理学会。Comr Physiol 1：1795-1835,2011。
Organic anions and cations (OAs and OCs, respectively) comprise an extraordinarily diverse array of compounds of physiological, pharmacological, and toxicological importance. The kidney, primarily the renal proximal tubule, plays a critical role in regulating the plasma concentrations of these organic electrolytes and in clearing the body of potentially toxic xenobiotics agents, a process that involves active, transepithelial secretion. This transepithelial transport involves separate entry and exit steps at the basolateral and luminal aspects of renal tubular cells. Basolateral and luminal OA and OC transport reflects the concerted activity of a suite of separate proteins arranged in parallel in each pole of proximal tubule cells. The cloning of multiple members of several distinct transport families, the subsequent characterization of their activity, and their subcellular localization within distinct regions of the kidney, now allows the development of models describing the molecular basis of the renal secretion of OAs and OCs. New information on naturally occurring genetic variation of many of these processes provides insight into the basis of observed variability of drug efficacy and unwanted drug-drug interactions in human populations. The present review examines recent work on these issues. (C) 2011 American Physiological Society. Compr Physiol 1: 1795-1835, 2011.